基于难治性精神分裂症脑神经机制的潜在治疗靶点及疗效预测研究进展  

Research progress on characteristics of brain neural mechanism and potential therapeutic targets of treatment refractory schizophrenia

作　　者：王莹[1] 程永莹 孙芸[1] 田红军 方涛[2] 禚传君 Wang Ying;Cheng Yongying;Sun Yun;Tian Hongjun;Fang Tao;Zhuo Chuanjun(PNGC Lab,Tianjin Anding Hospital,Teaching School of Clinical Psychiatry Affiliated to Tianjin Medical University,Tianjin 300222,China;Key Laboratory of Sensory System Damage of Schizophrenia,Tianjin 4th Centre Hospital,Tianjin 4th Centre Hospital Affiliated to Tianjin Medical University,Tianjin 4th Centre Hospital Affiliated to Nankai University,Tianjin 300140,China)

机构地区：[1]天津市安定医院,天津医科大学精神卫生临床医院精神病学脑影像实验室,300222 [2]天津市第四中心医院,天津医科大学附属天津市第四中心医院,南开大学附属天津市第四中心医院,精神分裂症感觉系统损害重点实验室,300140

出　　处：《神经疾病与精神卫生》2020年第7期494-498,共5页Journal of Neuroscience and Mental Health

基　　金：国家自然科学基金项目(81871052)。

摘　　要：精神分裂症病理机制不明,即使经充分有效治疗后,仍有30%以上的患者由于疗效欠佳发展为难治性精神分裂症,造成重大疾病负担。现从难治性精神分裂症治疗现状、神经病理机制、潜在治疗靶点及疗效预测等方面进行综述,希望能够为难治性精神分裂症的病理机制研究及治疗提供参考。The pathological mechanism of schizophrenia remain unclear.More than 30%of schizophrenic patients become treatment refractory schizophrenia due to poor curative effect,even after adequate and effective treatment.It results in significant disease burden.This article reviews the current treatment,neuropathological mechanism,potential therapeutic targets and curative effect prediction of refractory schizophrenia,hoping to provide reference for the pathological mechanism research and treatment of refractory schizophrenia.

关 键 词：难治性精神分裂症 影像遗传 机器学习 综述 

分 类 号：R749.3[医药卫生—神经病学与精神病学]