磁共振弥散张量成像在帕金森病诊断与定量分析中的应用价值  

Application value of diffusion tensor imaging in the diagnosis and quantitative analysis of parkinson’s disease

作　　者：郭龙军 梁长华[1] GUO Longjun;LIANG Changhua(Department of Radiology,The First Affiliated Hospital of Xinxiang Medical University,Henan 453100,China)

机构地区：[1]新乡医学院第一附属医院放射科,河南新乡453100 [2]首都医科大学附属北京康复医院放射科,北京100144

出　　处：《中风与神经疾病杂志》2020年第10期900-903,共4页Journal of Apoplexy and Nervous Diseases

基　　金：首都医科大学附属北京康复医院科技发展专项(No.2019-012)。

摘　　要：目的探讨磁共振弥散张量成像(DTI)在帕金森病(PD)诊断与定量分析中的应用价值。方法选取2017年12月-2019年10月我院收治的PD患者45例作为观察组,同期健康体检者39例作为对照组。两组均接受DTI检查,测量各向异性指数(FA)及表观扩散系数(ADC)值,进行统计学分析。结果观察组丘脑、黑质FA值均低于对照组,差异有统计学意义(P<0.05)。两组丘脑、黑质、脑桥、小脑上脚及中脚ADC值比较差异均无统计学意义(P>0.05)。ROC曲线分析显示:丘脑FA值、黑质FA值诊断PD的AUC分别为0.704、0.798(均P<0.05)。Hoehn-Yahr中期PD患者黑质FA值低于早期,丘脑ADC值高于早期,差异有统计学意义(P<0.05)。Pearson相关性分析显示:黑质FA值与PD患者Hoehn-Yahr分期呈负相关(r=-0.457,P=0.002);丘脑ADC值与PD患者Hoehn-Yahr分期呈正相关(r=0.405,P=0.006)。结论DTI对PD具有定量诊断价值,且黑质FA值、丘脑ADC值与PD病情具有相关性。Objective To investigate the application value of diffusion tensor imaging(DTI)in the diagnosis and quantitative analysis of parkinson's disease(PD).Methods Forty five patients with PD in our hospital from December 2017 to October 2019 were selected as the observation group,and 39 healthy people were selected as the control group.Two groups were examined by DTI,and the fractional anisotropy(FA)and apparent diffusion coefficient(ADC)value were measured and analyzed statistically.Results The FA value of thalamus and substantia nigra in the observation group were lower than those of the control group(P<0.05).There was no significant difference in ADC value of thalamus,substantia nigra,pons,superior cerebellar peduncle and middle peduncle between the two groups(P>0.05).The results of ROC curve showed that:the AUC of FA value in thalamus and substantia nigra was 0.704 and 0.798,respectively(P<0.05).The FA value of substantia nigra in PD patients with mid-Hoehn-Yahr stage was lower than that of early stage,and the ADC value of thalamus was higher than that of early stage(P<0.05).Pearson correlation analysis showed that:the FA value of substantia nigra was negatively correlated with Hoehn-Yahr stage of PD patients(r=-0.457,P=0.002);the ADC value of thalamus was positively correlated with Hoehn-Yahr stage of PD patients(r=0.405,P=0.006).Conclusion DTI has a quantitative diagnostic value for PD,and FA value of substantia nigra and ADC value of thalamus were correlated with PD condition.

关 键 词：帕金森病 磁共振弥散张量成像 表观扩散系数 各向异性指数 定量诊断 

分 类 号：R742.5[医药卫生—神经病学与精神病学]