甘草酸单铵半胱氨酸氯化钠注射液治疗儿童肝损伤的真实世界研究  

A real-world study on the treatment of liver injury in children with monoammonium glycyrrhizinate and cysteine and sodium chloride injection

作　　者：李文辉 唐洪侠[2] 贾彬[1] 崔玲[1] 马慧轩 李颖佳 冉冀娜 LI Wenhui;TANG Hongxia;JIA Bin;CUI Ling;MA Huixuan;LI Yingjia;RAN Ji'na(Department of Infectious Diseases and Gastroenterology,Hebei Children's Hospital affiliated to Hebei Medical University,Shijiazhuang050030,China;Department of Neurology,Hebei Children's Hospital affiliated to Hebei Medical University,Shijiazhuang050030,China)

机构地区：[1]河北医科大学附属河北省儿童医院感染与消化科,河北石家庄050030 [2]河北医科大学附属河北省儿童医院神经内科,河北石家庄050030

出　　处：《中国现代医生》2020年第28期121-124,共4页China Modern Doctor

摘　　要：目的通过对甘草酸单铵半胱氨酸氯化钠注射液用药情况进行真实世界研究分析,了解其在肝损伤患儿中的临床用药特征、有效性和安全性。方法以2018年1月~2019年7月河北省儿童医院感染消化科电子病历为数据来源,以连续3 d以上处方使用甘草酸单铵半胱氨酸氯化钠注射液治疗肝损伤的0~14岁患儿为研究对象,对患儿基线资料、入院诊断、临床用药信息、临床治疗的有效性和安全性等进行分析。结果共155例患儿符合本研究的纳入排除标准并用于分析,其中3岁及以下儿童占64.52%,患儿年龄中位数为1岁8个月(1个月1天~14岁);甘草酸单铵半胱氨酸氯化钠注射液临床多用于感染性疾病引起肝损伤的治疗;临床使用时常联用抗病毒药物或其他药物;57.42%的患儿单次用药剂量为>50~100 mL;57.42%的患儿用药疗程为8~14 d。本研究中患儿用药治疗的总有效率为93.55%,未发现不良反应。结论甘草酸单铵半胱氨酸氯化钠注射液治疗0~14岁的肝损伤儿童临床疗效高,且用药安全。Objective To analyze the real-world study of medication of monoammonium glycyrrhizinate and cysteine and sodium chloride injection,and to understand its clinical medication characteristics,effectiveness and safety in the children with liver injury.Methods From January 2018 to July 2019,the electronic medical records(EMRs)of the Department of Infectious Diseases and Gastroenterology in Hebei Children's Hospital were taken as data sources,and the children aged 0 to 14 who had suffered liver injury and been treated with monoammonium glycyrrhizinate and cysteine and sodium chloride injection for more than 3 consecutive days were taken as the subjects of research.The baseline data,admission diagnosis,clinical medication information,effectiveness and safety of clinical treatment of the patients were analyzed.Results A total of 155 patients met the inclusion and exclusion criteria of this study and were used for analysis.Among them,the children under 3 years old accounted for 64.52%,and the median age of the children was 1 year and 8 months(from 1 month and 1 d to 14 years old).Monoammonium glycyrrhizinate and cysteine and sodium chloride injection was mostly used in the treatment of liver injury caused by infectious diseases.In clinical use,it was often combined with antiviral drugs or other drugs.The single dose of 57.42%patients was>50-100 mL;57.42%patients were treated for 8 to 14 d.In this study,the total effective rate of medication for the patients was 93.55%,and no adverse reactions were found.Conclusion Monoammonium glycyrrhizinate and cysteine and sodium chloride injection has high clinical efficacy and sound medication safety in treating the children with liver injury aged 0 to 14.

关 键 词：肝损伤 临床用药特征 有效性 安全性 真实世界研究 甘草酸单铵半胱氨酸氯化钠注射液 

分 类 号：R575.5[医药卫生—消化系统]