非酒精性脂肪肝引发冠心病的影响因素  

Influencing factors of non-alcoholic fatty liver disease causing coronary heart disease

作　　者：李月红[1] 赵红星[1] LI Yuehong;ZHAO Hongxing(Department of Cardiology,Huzhou First People's Hospital in Zhejiang Province,Huzhou313000,China)

机构地区：[1]浙江省湖州市第一人民医院心内科,浙江湖州313000

出　　处：《中国现代医生》2020年第29期106-109,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2018KY774)。

摘　　要：目的研究非酒精性脂肪肝(NAFLD)与冠心病的患病风险及相关影响因素。方法采用回顾性分析方法,收集2017年7月~2019年7月我院收治的79例非酒精性脂肪肝患者临床资料作为对照组,另选取同时期于我院体检有非酒精性脂肪肝联合冠心病的40例患者的临床资料作为观察组。详细记录其一般情况,包括性别、年龄、吸烟史、体质量指数(BMI)、左室射血分数(LVEF)、心肌梗死或冠脉介入史、高血压、糖尿病及相关实验室指标[总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]。经单因素、多因素分析非酒精性脂肪肝引发冠心病的相关影响因素。结果经非条件多项Logistic回归分析证实,吸烟、高血压、TC>200 mg/dL以及HDL-C<50 mg/dL均可能是非酒精性脂肪肝患者诱发冠心病的危险因素(OR>1,P<0.05)。结论吸烟、高血压、总胆固醇含量过高和高密度脂蛋白含量过高可能诱发NAFLD患者发生冠心病,临床上应积极采取有效的措施进行预防。Objective To study the risk of non-alcoholic fatty liver disease(NAFLD)and coronary heart disease,as well as relevant influencing factors.Methods A total of 79 patients with non-alcoholic fatty liver disease admitted to our hospital from July 2017 to July 2019 were enrolled in the control group,and 40 patients with non-alcoholic fatty liver disease combined with coronary heart disease admitted to our hospital during the same period were enrolled in the observation group.Their clinical data were collected to conduct retrospective analysis.Their general information was recorded in detail,including gender,age,smoking history,body mass index(BMI),left ventricular ejection fraction(LVEF),history of myocardial infarction or coronary intervention,hypertension,diabetes and related laboratory indicators(total cholesterol[TC],low-density lipoprotein cholesterol[LDL-C],high-density lipoprotein cholesterol[HDL-C]).Univariate and multivariate analyses were performed to study the related factors of nonalcoholic fatty liver disease causing coronary heart disease.Results Nonconditional multinomial Logistic regression analysis was conducted and it was confirmed that smoking,hypertension,TC>200 mg/dL and HDL-C<50 mg/dL might all be the inducing factors for coronary heart disease in patients with non-alcoholic fatty liver disease(OR>1,P<0.05).Conclusion Smoking,high blood pressure,high total cholesterol and a high level of high-density lipoprotein cholesterol may induce coronary heart disease in NAFLD patients,which should be prevented by clinical effective measures.

关 键 词：非酒精性脂肪肝 冠心病 患病风险 影响因素 

分 类 号：R781.63[医药卫生—口腔医学]