肿瘤相关巨噬细胞在卵巢癌耐药中的作用  

作　　者：张海杏 孟凡良[2] 龚时鹏[2] 

机构地区：[1]南方医科大学基础医学院,广州510515 [2]南方医科大学南方医院妇产科

出　　处：《妇产与遗传（电子版）》2020年第3期51-55,共5页Obstetrics-Gynecology and Genetics (Electronic Edition)

摘　　要：卵巢癌是常见的女性生殖系统恶性肿瘤之一,其病死率在妇科癌症中居于首位。目前卵巢癌的常规治疗方法是手术并辅以化疗,该治疗方案虽然可以使部分患者得到缓解,但5年复发率仍高达50%~70%。复发性卵巢癌最终会对化疗药物产生耐药性,这是目前治疗中的一个紧迫问题。耐药的发生是由细胞与微环境共同决定的,肿瘤相关巨噬细胞(Tumorassociated macrophages,TAMs)是肿瘤微环境的主要成分之一。TAMs可以通过导致血管及淋巴管的生成、抑制适应性免疫、以及与肿瘤干细胞相互作用等导致卵巢癌耐药的发生。本文主要对TAMs在卵巢癌耐药中的作用及研究进展做一综述,以便为寻找新的抗卵巢癌药物提供借鉴。Ovarian cancer is one of the common malignancies of female reproductive system,and has the most mortality rate in gynecologic cancer.At present,the conventional treatment for ovarian cancer is surgery combined with chemotherapy.Although this regimen could alleviate some patients,but the 5-year recurrence rate is still as high as 50%~70%.Recurrent ovarian cancer will eventually develop resistance to chemotherapy and which is an urgent problem in the clinical practice.Tumor associated macrophages(TAMs)are one of the main components of tumor microenvironment.TAMs can promote the development of drug resistance by promoting the formation of blood vessels and lymphatic vessels,inhibiting adaptive immunity,and interacting with tumor stem cells in ovarian cancer.In this article,the function and research progress of TAMs in ovarian cancer resistance were reviewed,in order to provide reference for finding new anti ovarian cancer drugs in the future.

关 键 词：卵巢肿瘤 化疗耐药 肿瘤相关巨噬细胞 

分 类 号：R737.3[医药卫生—肿瘤]