血清CD26在糖尿病合并结直肠腺瘤-腺癌序列中的表达及其意义  

Expression and significance of serum CD26 in patients with diabetes mellitus complicated with colorectal adenoma-adenocarcinoma sequence

作　　者：王亚丹[1] 葛将 黄树峰[2] 吴静[3] WANG Yadan;GE Jiang;HUANG Shufeng;WU Jing(Department of Gastroenterology,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038;Department of Oncology,Daqing People’s Hospital;Department of Gastroenterology,Beijing Friendship Hospital,Capital Medical University,National Clinical Research Center for Digestive Diseases,Beijing Digestive Disease Center,Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases,China)

机构地区：[1]首都医科大学附属北京世纪坛医院消化内科,北京100038 [2]大庆市人民医院肿瘤三科 [3]首都医科大学附属北京友谊医院消化科,国家消化系统疾病临床医学研究中心,北京市消化疾病中心,消化疾病癌前病变北京市重点实验室

出　　处：《胃肠病学和肝病学杂志》2020年第11期1226-1230,共5页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的评价血清CD26在糖尿病合并结直肠肿瘤(癌及腺瘤)患者循环中的表达情况及其临床意义。方法收集2012年1月至2013年12月在首都医科大学附属北京世纪坛医院消化内科住院并行电子结肠镜检查的患者214例,其中结直肠腺瘤患者68例,28例合并糖尿病;结直肠腺癌患者66例,26例合并糖尿病;内镜检查未见异常者80例,40例合并糖尿病,作为正常对照组。所有入组患者均通过ELISA法检测血清CD26浓度,电化学发光法检测血清CEA浓度,并进行统计学分析。结果从内镜阴性到腺瘤到腺癌,血清CD26逐渐升高,各组间比较,差异有统计学意义(P<0.05)。糖尿病合并结直肠腺癌患者血清CD26、CEA水平明显高于无糖尿病的结直肠腺癌患者,差异有统计学意义(P<0.05)。结论血清CD26水平从内镜阴性到腺瘤到腺癌逐渐升高,提示其可能成为诊断糖尿病合并结直肠癌的生物标志物。Objective To evaluate the expression and clinical significance of serum CD26 in patients with diabetes mellitus complicated with colorectal tumor(carcinoma and adenoma).Methods A total of 214 patients who were admitted to the Department of Gastroenterology in Beijing Shijitan Hospital,Capital Medical University from Jan.2012 to Dec.2013 were collected,including 68 patients with colorectal adenoma(28 patients with diabetes),66 patients with colorectal adenocarcinoma(26 patients with diabetes),and 80 cases were not abnormal by endoscopy(40 patients with diabetes)as normal control group.Serum CD26 concentration was detected by ELISA method,serum CEA concentration was detected by electrochemiluminescence method,and statistical analysis was carried out.Results From normal to adenoma to adenocarcinoma,the serum CD26 increased gradually,and there was significant difference among the groups(P<0.05).The levels of serum CD26 and CEA in patients with diabetes mellitus complicated with colorectal adenocarcinoma were significantly higher than those without diabetes mellitus(P<0.05).Conclusion The level of serum CD26 increases gradually from normal to adenoma to adenocarcinoma,suggesting that it may become a new biomarker for the diagnosis of diabetes mellitus complicated with colorectal cancer.

关 键 词：结直肠腺瘤 结直肠腺癌 CD26 糖尿病 

分 类 号：R735.3[医药卫生—肿瘤]