住院患者红细胞血型不规则抗体特点调查  

Investigation and analysis of RBC-irregular antibodies in hospitalized patients

作　　者：陈碧乐[1] 蔡雪娇[1] 叶银才 林双女 卓盛林 谢作听[1] CHEN Bile;CAI Xuejiao;YE Yincai;LIN Shuangnyu;ZHUO Shenglin;XIE Zuoting(Department of Blood Transfusion,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325015,China;Department of Blood Transfusion,Yongjia County People’s Hospital,Wenzhou 325100,China)

机构地区：[1]温州医科大学附属第一医院输血科,浙江温州325015 [2]永嘉县人民医院输血科,浙江温州325100

出　　处：《温州医科大学学报》2020年第11期915-918,共4页Journal of Wenzhou Medical University

基　　金：温州市科技计划项目(Y20170821)。

摘　　要：目的:调查分析住院患者红细胞血型不规则抗体的阳性率、分布特点、特异性及其免疫球蛋白类型。方法:收集温州医科大学附属第一医院2017年11月至2019年10月期间所有住院患者,筛选出红细胞血型不规则抗体阳性标本并统计分析抗体的阳性率、分布特点、特异性及其免疫球蛋白类型。结果:住院患者的红细胞血型不规则抗体总阳性率为0.29%(834/287030),其中男性患者抗体阳性率为0.20%,女性患者抗体阳性率为0.38%,组间比较差异有统计学意义(P<0.05)。红细胞血型不规则抗体分布特点:女性患者抗体阳性构成比为66.99%(558/834),男性患者抗体阳性构成比为33.01%(276/834);有妊娠史但无输血史的女性患者抗体阳性构成比为72.22%为(403/588),无妊娠史但有输血史的女性患者抗体阳性构成比为5.38%(30/588),既有妊娠史又有输血史的女性患者抗体阳性构成比为19.35%为(108/588),既无妊娠史又无输血史的女性患者抗体阳性构成比为3.05%(17/588);红细胞血型不规则抗体特异性:能确定抗体特异性的占比为54.80%(457/834),其中以Rh血型系统抗E抗体比例最高,占比27.58%。红细胞血型不规则抗体的免疫球蛋白类型:以单纯IgG类抗体为主,占比72.90%(632/834)。结论:住院患者红细胞血型不规则抗体阳性者以有妊娠史的女性患者为主,且不规则抗体特异性以IgG类抗E抗体最为常见。Objective:To investigate and analyze the positive rate,distribution characteristics,specificity and immunoglobulin types of RBC-irregular antibodies in hospitalized patients.Methods:Samples of all patients in our hospital between Nov.2017 and Oct.2019 were collected,with irregular samples of erythrocyte blood groups screened for a statistical analysis of positive antibodies,the positive rate,distribution characteristics,specificity and immunoglobulin types of antibodies.Results:Total positive rate of RBC-irregular antibodies in hospitalized patients was 0.29%(834/287030);the positive rate of antibody in male patients and female patients was 0.20%and 0.38%respectively.There was statistically difference between groups(P<0.05).RBC-irregular antibodies distribution had the following characteristics:the antibody-positive composition ratio of female patients was 66.99%(558/834),while that of male patients was 33.01%(276/834).The proportion of antibody-positive was 72.22%(403/588)in women with history of pregnancy but no history of blood transfusion,and that was 5.38%(30/588)in women with no history of pregnancy but history of blood transfusion;the antibody-positive ratio of female patients with history of both pregnancy and blood transfusion was 19.35%(108/588),while the antibodypositive ratio of female patients without history of either pregnancy or blood transfusion was 3.05%(17/588).RBC-irregular antibodies specificity showed that 54.80%(457/834)of antibody specificity could be determined,of which the Rh blood group system had the highest proportion of anti-E antibodies,accounting for 27.58%.Immunoglobulin types of RBC-irregular antibodies were mainly IgG antibodies,accounting for 72.90%(632/834).Conclusion:In patients with RBC-irregular antibodies positive in this hospital were mainly female patients with pregnancy history,and the specificity of irregular antibodies was most commonly IgG anti-E antibodies.

关 键 词：红细胞血型 不规则抗体 调查分析 

分 类 号：R733[医药卫生—肿瘤]