超微血管成像技术检测颈动脉斑块内新生血管联合血浆脂蛋白磷脂酶A2预测脑梗死再发的价值  

Prediction of recurrent cerebral infarction by the neovascularization in carotid plaque using superb micro vascular imaging and lipoprotein-associated pospholipase A2

作　　者：杨帆 陈娜 唐亮 YANG Fan;CHEN Na;TANG Liang(Department of Ultrasonography,Binhaiwan Central Hospital of Dongguan,Dongguan 523900,China)

机构地区：[1]广东省东莞市滨海湾中心医院超声科,广东东莞523900 [2]广东省东莞市滨海湾中心医院神经内科,广东东莞523900

出　　处：《中国中西医结合影像学杂志》2020年第6期590-593,共4页Chinese Imaging Journal of Integrated Traditional and Western Medicine

基　　金：东莞市社会科技发展(一般)项目(201950715025887)。

摘　　要：目的:探讨使用超微血管成像技术(SMI)评价颈动脉斑块内新生血管联合血浆脂蛋白磷脂酶A2(Lp-PLA2)预测脑梗死再发的价值。方法:收集初发脑梗死患者120例进行血浆Lp-PLA2和颈动脉斑块内新生血管的SMI检测;随访1年后,比较再发组和未再发组血浆Lp-PLA2表达值、斑块内新生血管检测结果的差异;应用ROC曲线评估斑块内新生血管和血浆Lp-PLA2预测脑梗死再发的敏感度和特异度。结果:2组血浆Lp-PLA2表达值、斑块内新生血管分级差异均有统计学意义(均P<0.05)。SMI检测颈动脉斑块内新生血管联合血浆Lp-PLA2预测脑梗死再发的敏感度和特异度分别为68.1%(32/47)和87.7%(64/73),联合预测变量AUC最大。结论:SMI检测颈动脉斑块内新生血管联合血浆Lp-PLA2预测脑梗死再发具有更高的敏感度和特异度,值得临床应用。Objective:To evaluate the utility of the prediction of recurrent cerebral infarction by the neovascularization using superb micro vascular imaging(SMI)and serum lipoprotein-associated pospholipase A2(Lp-PLA2).Methods:120 patients with first cerebral infarction were studied by SMI and Lp-PLA2.The condition of recurrent cerebral infarction was followed up in one year.The objects of the study were divided into recurrent group and non-recurrent group,then the serum Lp-PLA2 and the neovascularization in carotid plaque between the two groups were compared.The utility of the prediction of recurrent cerebral infarction by neovascularization grade and the serum Lp-PLA2 was evaluated by ROC curve.Results:The differences of the neovascularization grade and the serum Lp-PLA2 between the two groups were significant(both P<0.05).The sensitivity and specificity to prediction of recurrent cerebral infarction by the combination parameter was 68.1%and 87.7%.The AUC for the combination parameters was the largest.Conclusion:The combined utilization of neovascularization in carotid plaque by SMI and the serum Lp-PLA2 could be a valid indicator to predict the recurrent cerebral infarction and can be used for clinical.

关 键 词：超微血管成像 血浆 磷脂酶A2 大脑梗塞 新生血管化 病理性 复发 斑块 动脉粥样硬化性 颈动脉 预测 

分 类 号：R743.33[医药卫生—神经病学与精神病学]