妊娠期糖尿病患者血糖相关指标变化与不良母婴结局的相关性分析  

Correlation Analysis of Changes in Blood Glucose-related Indexes and Adverse Mother-Infant Outcomes in Patients with Gestational Diabetes

作　　者：李莎[1] 冯惠庆[1] 俞奇[1] 尚雪[1] LI Sha;FENG Hui-qing;YU Qi(Department of Obstetrics and Gynecology,Bo’ai Hospital of Zhongshan,Zhongshan,Guangdong,528400,China)

机构地区：[1]中山市博爱医院妇产科,广东中山528400

出　　处：《黑龙江医学》2020年第11期1496-1498,共3页Heilongjiang Medical Journal

基　　金：中山市卫生局科研基金项目(2017A020053)。

摘　　要：目的分析妊娠期糖尿病患者血糖相关指标变化与不良母婴结局的相关性。方法回顾性分析中山市博爱医院2017年1月—2019年12月期间收治的妊娠期糖尿病患者180例的临床资料,依据母婴结局分为不良组(n=60)、良好组(n=120)。比较两组血糖相关指标[空腹血糖(FBG)、餐后2 h血糖(PBG)、糖化血红蛋白(HbA1c)],并分析血糖相关指标与不良母婴结局的相关性。结果不良组的FBG、PBG、HbA1c水平明显高于良好组,差异有统计学意义(P<0.05);经二元logistic回归分析,血清FBG、PBG、HbA1c的方程依次为Y=-3.331+0.485X、Y=-5.328+0.522X、Y=-6.050+0.928X,表明血清FBG、PBG、HbA1c是导致妊娠期糖尿病患者发生不良母婴结局的危险因素(OR>1,P<0.05)。结论妊娠期糖尿病患者的血糖相关指标与不良母婴结局具有密切的相关性,且患者血糖相关指标水平越高,其发生不良母婴结局的风险越大,故临床上可通过检测患者的血糖指标,预测不良母婴结局的发生风险。Objective To analyze the correlation between changes in blood glucose-related indicators and adverse mother-infant outcomes in patients with gestational diabetes.Methods 180 patients of gestational diabetes admitted to Bo’ai Hospital of Zhongshan from January,2017 to December,2019 were retrospectively analyzed.According to maternal and infant outcomes,they were divided into poor group(n=60)and good group(n=120).The blood glucose-related indicators[fasting blood glucose(FBG),2 h postprandial blood glucose(PBG)and glycated hemoglobin(HbA1 c)]were compared,and the correlation between blood glucose-related indicators and adverse maternal and infant outcomes were analyzed.Results The levels of FBG,PBG and HbA1 c in the poor group were significantly higher than those in the good group,and the difference was statistically significant(P<0.05).After binary logistic regression analysis,the equations of serum FBG,PBG and HbA1 c were Y=-3.331+0.485 X,Y=-5.328+0.522 X,Y=-6.050+0.928 X,indicating that serum FBG,PBG,HbA1 c were risk factors for adverse maternal and infant outcomes in patients with gestational diabetes(OR>1,P<0.05).Conclusion The blood glucose-related indexes of patients with gestational diabetes are closely related to the adverse maternal and infant outcomes.The higher the level of blood glucose-related indexes,the greater the risk of adverse maternal and infant outcomes.Blood glucose-related indexes can be used to predict the risk of adverse mother and child outcomes.

关 键 词：妊娠期糖尿病 空腹血糖 糖化血红蛋白 不良母婴结局 相关性 

分 类 号：R781.64[医药卫生—口腔医学]