微芯片中磁性液滴的生成与操控综述  

Review on magnetic droplet generation and manipulation in microchips

作　　者：龙超 陈瑞 翟持 陈飞[1] 杨春曦[1] Chao LONG;Rui CHEN;Chi ZHAI;Fei CHEN;Chunxi YANG(Faculty of Chemical Engineering,Kunming University of Science and Technology,Kunming,Yunnan 650500,China)

机构地区：[1]昆明理工大学化学工程学院,云南昆明650500

出　　处：《过程工程学报》2020年第10期1134-1146,共13页The Chinese Journal of Process Engineering

基　　金：国家自然科学基金资助项目(编号:61364002,51866005)。

摘　　要：磁性液滴以其微尺度、多相流属性和非接触式操控特性,近年来因在生物细胞分离、靶向药物治疗等方面的成功应用受到来自科学界和企业界学者们的广泛关注,如何操控磁性液滴精确运动到设定位置是主要难点。本工作从磁性液滴的生成方式、运动基本机理及操控方法三个方面,对目前存在的主流磁性液滴生成与操控的方法进行了整理。目前对于磁性液滴的操控方法可分为三类,第一类是永磁铁-机械式操控方法:该方法将永磁铁放置在一个机械移动平台上,通过移动平台改变永磁铁与微芯片的距离进而改变磁场,最终实现操控液滴的目的;第二类是电磁铁-电气式操控方法:以高速照相机拍摄液滴运动的位置误差为检测信号,将检测信号传递给控制器,最终通过改变电磁铁的磁场强度实现对液滴的操控;第三类是永磁铁/电磁铁-电气式混合控制方法:通过将两者的优缺点进行互补,最终达到更优控制。总结了目前存在方法的缺陷和难点,指出了磁性液滴在未来发展中的一些可行的研究方法和研究方向。要点:(1)综述了磁性液滴的应用和合成,总结了磁性液滴处理的主要方法的优缺点。(2)综述了磁液滴形成的方法,包括磁动力法、多相流法和电动力法。(3)总结了磁性液滴在磁场中的力学分析,给出了磁性液滴的动力学方程。(4)综述了磁性液滴的操控方法,包括永磁铁操控、电磁铁操控和混合操控,并分析了各自的特点。In recent years, magnetic droplets with microscale, multiphase and contactless properties have received wide attentions from researcher of science and business for their successful applications in biological cell separation and targeted drug therapy. However, the main challenge is how to manipulate magnetic droplets approaching the set position accuracy. Therefore, three aspects including the current methods of generating and manipulating magnetic droplets, the basic mechanism of magnetic droplet manipulation and their control mechanism were summarized in this work. At present, the control methods for magnetic droplets can be divided into three categories. The first type was the permanent magnets-mechanical method where permanent magnets were placed on a mechanically mobile platform. By means of moving the platform, the distance between the permanent magnet and the microchip was changed and then the magnetic field intensity was also regulated. Moreover, the dynamic magnetic droplets were controlled. The second type was the electromagnet-electric method where the situation errors of droplets were detected by high-speed camera and sent to controller and the prebuilding mathematical model to obtain control output in order to regulate magnetic field intensity for manipulates the magnetic droplet. The third type was permanent magnets/electromagnet-electric mixed method where advantages of two methods mentioned above were combined to manipulate magnetic droplets for better control. Finally, the drawbacks and difficulties of current methods of magnetic droplets generating and manipulating were summarized and further possible research techniques and research fields were prospected. Key learning points:(1) The application and synthesis of magnetic droplets were introduced, the advantages and disadvantages of the main methods for manipulate magnetic droplet were summarized.(2) The methods of magnetic droplet formation were summarized including magnetic dynamic method, multiphase flow method and electric dynamic method.(3)

关 键 词：磁性液滴 液滴生成 过程控制 动力学模型 

分 类 号：TN492[电子电信—微电子学与固体电子学]