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作 者:关嘉琦 李柏良[1] 焦雯姝 李慧臻 岳莹雪 李娜[1] 史佳鹭 赵莉[1] 霍贵成[1] GUAN Jiaqi;LI Bailiang;JIAO Wenshu;LI Huizhen;YUE Yingxue;LI Na;SHI Jialu;ZHAO Li;HUO Guicheng(Key Laboratory of Dairy Science,Ministry of Education,Northeast Agricultural University,Harbin 150030,China)
机构地区:[1]东北农业大学乳品科学教育部重点实验室,黑龙江哈尔滨150030
出 处:《食品科学》2020年第21期278-285,共8页Food Science
基 金:“十三五”国家重点研发计划重点专项(2017YFD0400303)。
摘 要:肠道细胞的正常增殖分化、黏膜屏障完整性作为评价肠道发育的重要指标,很大程度上决定了人和动物的能量稳态和整体生长性能,是决定人和动物生理稳态的根本因素。而良好的微生物-宿主通讯机制及其共生关系对肠道发育及稳态具有积极作用。近年来国内外大量研究显示肠道微生物参与调控肠道增殖分化,其中益生菌(主要是乳酸菌)发挥了极重要的益生作用。本文详述了肠道组成及发育机制,并从益生菌的自身组分(如菌毛蛋白、细胞壁成分等)、代谢产物(丁酸及其盐类)、肠道菌群的多样性和定植状态3个方面对益生菌促进肠道上皮细胞与肠道干细胞增殖分化、增强黏膜屏障功能、维持肠道良好形态的功能及其干预机制的研究进展进行综述,旨在加深和完善关于益生菌调控肠道发育的认识。As important indicators to evaluate intestinal development,normal proliferation and differentiation of intestinal cells and the integrity of the mucosal barrier largely determine energy homeostasis and overall growth performance of humans and animals,thereby being considered as fundamental determinants of physiological homeostasis in humans and animals.Good microbe-host communication and their symbiotic relationship have positive effects on intestinal development and homeostasis.In recent years,a large number of studies worldwide have shown that intestinal microorganisms are involved in the regulation of intestinal proliferation and differentiation,including lactic acid bacteria which have been reported for probiotic properties.In order to provide insights into the role of probiotics in regulating intestinal development,intestinal composition and developmental mechanism are described in detail,and the functions of probiotics in promoting the proliferation and differentiation of intestinal epithelial cells and intestinal stem cells,enhancing intestinal mucosal barrier function,and maintaining good intestinal morphology as well as the underlying mechanisms are reviewed from three aspects,including probiotic cell components(such as pilin and cell wall components),metabolites(butyric acid and butyrate),and intestinal flora diversity and colonization status.
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