自身免疫性肝病药物治疗的研究进展  

Research Progress of Drug Therapy for Autoimmune Liver Disease

作　　者：赵晓春[1] 钟庆[1] 郭熙清[1] 刘书宏[1] 梁尘格 ZHAO Xiaochun;ZHONG Qing;GUO Xiqing;LIU Shuhong;LIANG Chenge(Department of Hepatology,Chongqing Three Gorges Central Hospital,Chongqing 404000,China)

机构地区：[1]重庆三峡中心医院肝病科,重庆404000

出　　处：《医学综述》2020年第21期4263-4267,共5页Medical Recapitulate

摘　　要：因自身免疫功能异常导致的肝脏炎症性疾病被称为自身免疫性肝病(ALD)。ADL治疗有一定难度,一直是临床关注的重难点。标准药物方案是治疗ALD的重要手段,主要用药类型包括皮质激素、免疫抑制剂等,但不同类型的ALD有各自的特点,需针对疾病本身为患者选择针对性的药物治疗,才能确保疗效。免疫性肝炎在ALD中常见,治疗药物常见糖皮质激素、免疫抑制剂,其他类型的ALD则主要使用皮质激素、熊脱氧胆酸等药物治疗,还有其他新药尚处于研发阶段。Inflammatory diseases of the liver caused by abnormal autoimmune functions are called autoimmune liver diseases(ALD).ALD treatment has certain difficulties and has always been a major difficulty in clinical attention.The standard drug regimen is an important method for the treatment of ALD.The main types of medication include corticosteroids and immunosuppressants.However,different types of ALD have their own characteristics,so it is necessary to select targeted drug treatments for patients according to the disease type to ensure the efficacy.Immune hepatitis is common in ALD,and the common therapeutic drugs include glucocorticoids and immunosuppressants.Other types of ALD mainly use corticosteroids,ursodeoxycholic acid for treatment,while there are other new drugs still in the research stage.

关 键 词：自身免疫性肝炎 胆汁性胆管炎 原发性硬化性胆管炎 药物治疗 

分 类 号：R575[医药卫生—消化系统]