LPS在结直肠癌中的作用机制及研究进展  

Research Progress of LPS in Colorectal Cancer

作　　者：孟静 李云峰[1] MENG Jing;LI Yun-feng(Colorectal Cancer Clinical Research Center,Third Affiliated Hospital of Kunming Medical University/Yunnan Provincial Cancer Hospital,Kunming 650118,China)

机构地区：[1]昆明医科大学第三附属医院/云南省肿瘤医院,大肠癌临床研究中心,云南昆明650118

出　　处：《肿瘤学杂志》2020年第10期918-921,共4页Journal of Chinese Oncology

基　　金：国家自然科学基金(81560472)。

摘　　要：内毒素脂多糖(lipopolysaccharid,LPS)作为一种重要的炎症诱导因子,因参与炎症发生的多个环节而被认知,近年来研究发现LPS在肿瘤的生成、转移及药物抵抗等多个方面同样发挥重要作用。大量的革兰阴性细菌在肠道中定植,LPS作为革兰阴性细菌的主要产物,如何在结直肠癌中发挥作用引起重视。全文就LPS在结直肠癌中的最新研究进展进行综述,以期为结直肠癌发生发展的机制提供新的研究思路。As an important inflammation-inducing factor,endotoxin lipopolysaccharide(LPS)is involved in many aspects of inflammation.A large number of Gram-negative bacteria are colonized in the intestine,and LPS is their main products,the relationship between LPS and colorectal cancer has attracted attention.Recent studies have revealed that LPS is also involved in tumor development,metastasis and drug resistance.This article will focus on the latest research progress of LPS in colorectal cancer,to provide new research ideas for the mechanism of colorectal cancer development.

关 键 词：结直肠肿瘤 内毒素脂多糖 肠道细菌 肿瘤微环境 

分 类 号：R735.34[医药卫生—肿瘤]