CD15及Ki-67表达水平与乳腺癌患者病理参数及5年存活率的关系分析  

Expression Levels of CD15 and Ki-67 and Their Relationship with Pathological Parameters and 5-year Survival Rates of Breast Cancer Patients

作　　者：沈玲[1] 李海滨 罗玉群[1] 杨辉[1] SHEN Ling;LI Hai-bin;LUO Yu-qun;YANG Hui(Department of Breast Surgery,Qinghai Hospital of Traditional Chinese Medicine,Xining 810000,China)

机构地区：[1]青海省中医院乳腺科,西宁810000

出　　处：《解放军医药杂志》2020年第11期40-44,共5页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：青海省科学技术厅应用基础研究项目(2015-ZJ-504)。

摘　　要：目的探讨CD15抗原及Ki-67表达水平与乳腺癌患者病理及5年存活率的关系。方法选取2014年5月-2015年5月我院收治的乳腺癌患者手术切除的癌组织和癌旁组织(距病变部位>5 cm处,且证实为无癌浸润)石蜡标本各90例为研究对象。检测乳腺癌组织中CD15、Ki-67的表达并分析二者与乳腺癌临床病理、5年存活率的关系。结果乳腺癌组织中CD15、Ki-67的阳性表达率高于癌旁组织(P<0.05)。TNM分期Ⅱ~Ⅲ期、合并淋巴结转移的乳腺癌组织CD15、Ki-67的阳性表达率均较高(P<0.05),出现神经侵犯、直径≥2 cm的乳腺癌组织Ki-67的阳性表达率较高(P<0.05)。不同类型的乳腺癌组织Ki-67的阳性表达率比较差异有统计学意义(P<0.05)。乳腺癌组织中CD15、Ki-67表达呈正相关(r=0.406,P=0.008)。本组90例乳腺癌患者的5年总存活率为64.44%(58/90),CD15、Ki-67阳性表达组5年生存率均低于CD15、Ki-67阴性表达组(P<0.05)。结论CD15、Ki-67表达阳性与乳腺癌TNM分期、淋巴结转移有关,Ki-67的阳性表达与乳腺癌的肿瘤类型、大小、神经侵犯相关,二者与乳腺癌患者的5年存活率密切相关。Objective To explore the relationship between expression levels of CD15 antigen and Ki-67 and pathological parameters,5-year survival rates of breast cancer patients.Methods Ninety paraffin specimens of surgical excision and 90 paraffin specimens of adjacent normal tissues(longer than 5 cm away from the lesion,confirmed as cancer-free infiltration)from the breast cancer patients who were admitted from May 2014 to May 2015 were enrolled as the research subjects.The expression levels of CD15 and Ki-67 in breast cancer tissues were detected by immunohistochemmistry.And their relationship with clinical pathological parameters and 5-year survival rates in breast cancer patients was analyzed.Results The positive expression rates of CD15 and Ki-67 in breast cancer tissues were higher than those in adjacent tissues(P<0.05).The positive expression rates of CD15 and Ki-67 were higher in TNM stageⅡ~Ⅲbreast cancer with lymph node metastasis(P<0.05),and the positive rate of Ki-67 in breast cancer with nerve invasion and diameter≥2 cm was higher(P<0.05).The positive expression rate of Ki-67 in different types of breast cancer was significantly different(P<0.05).There was a positive correlation between the expression of CD15 and Ki-67 in breast cancer(r=0.406,P=0.008).The 5-year overall survival rate of 90 breast cancer patients was 64.44%(58/90).The 5-year survival rate of CD15 and Ki-67 positive groups was lower than that of CD15 and Ki-67 negative expression groups(P<0.05).Conclusion The positive expression of CD15 and Ki-67 is related to TNM staging and lymph node metastasis of breast cancer.The positive expression of Ki-67 is related to tumor type,size and nerve invasion of breast cancer.Both are closely related to 5-year survival rates of breast cancer patients.

关 键 词：乳腺肿瘤 抗原 CD15 KI-67抗原 5年存活率 肿瘤分期 肿瘤转移 危险因素 

分 类 号：R737.9[医药卫生—肿瘤]