Preferential solvation of pomalidomide,an anticancer compound,in some binary mixed solvents at 298.15 K  

作　　者：Mohsen Padervand Shima Naseri Hadi Chahiyan Boroujeni 

机构地区：[1]Department of Chemistry,Faculty of Science,University of Maragheh,Maragheh,Iran [2]Department of Chemistry and Biology,Farhangian Teacher Training University,Mashhad Branch,Mashhad,Iran

出　　处：《Chinese Journal of Chemical Engineering》2020年第10期2626-2633,共8页中国化学工程学报（英文版）

摘　　要：Preferential solvation of pomalidomide(PMD)was explored in dimethyl sulfoxide(DMSO)-dimethylformamide(DMF),DMSO-tetrahydrofuran(THF),DMSO-methanol(Me OH),DMSO-isopropanol,DMSO-water,water-DMF,water-THF,water-Me OH,and water–isopropanol binary mixed solvents at 298.15 K.Bosch-Rose model was utilized to determine the electronic transition energies(ET)and other preferential solvation parameters,describing solute-solute and solute-solvent interactions.We found thatλmaxsituation shifted with dielectric constant of the pure solvents meaningfully.According to the obtained results,ETenhanced andλmaxshifted to the lower wavelengths as the percentage of DMSO decreased in the binary mixtures,remarking the important role of DMSO for stabilizing the excited state(π*)of PMD chromophore via efficient intermolecular solute-solvent interactions.In addition,the aqueous binary systems showed an optimum point for the ETvalues as the percentage of water changed in the solutions.The local mole fraction of the solvents in the cybotactic region was also estimated to describe the specific and non-specific interactions in the systems.

关 键 词：POMALIDOMIDE Preferential solvation Bosch-Rose model Binary solvents 

分 类 号：TQ460.1[化学工程—制药化工]