Objective To evaluate the efficacy and safety of bendamustine combined with pomalidomide and dexamethasone(BPD regimen)in the treatment of relapsed multiple myeloma(MM)with extramedullary disease.Methods This open,sin...
Refractory and relapsed multiple myeloma (RRMM) with plasma-cell leukemia (PCL) transformation is highly aggressive and resistant to conventional therapy. Novel therapeutics are needed for RRMM-transformed PCL. Seline...
financial support from National Natural Science Foundation of China (No.81603072)。
Pomalidomide is an immunomodulatory agent (IMiD) that has been approved by the US Food and Drug Administration (FDA) for clinical treatment of patients with multiple myeloma.In this work,we developed a sensitive and v...
supported by the National Key R&D Program(2019YFA0111001)of China.
Chimeric antigen receptor(CAR)T-cell therapy is mostly limited to hematological malignancies and has a poor effect on solid tumors.CAR T cells as a kind of immune cell may be affected by some immunomodulatory drugs su...
Preferential solvation of pomalidomide(PMD)was explored in dimethyl sulfoxide(DMSO)-dimethylformamide(DMF),DMSO-tetrahydrofuran(THF),DMSO-methanol(Me OH),DMSO-isopropanol,DMSO-water,water-DMF,water-THF,water-Me OH,and...