Prognostic value of primary tumor surgery in seminoma patients with distant metastasis at diagnosis:a population-based study  

作　　者：Sheng-Ming Jin Jia-Ming Wei Jun-Long Wu Bei-He Wang Hua-Lei Gan Pei-Hang Xu Fang-Ning Wan Wei-Jie Gu Yu Wei Chen Yang Yi-Jun Shen Ding-Wei Ye 

机构地区：[1]Department of Urology,Fudan University Shanghai Cancer Center,Shanghai 200032,China [2]Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China [3]Department of Pathology,Fudan University Shanghai Cancer Center,Shanghai 200032,China [4]Department of Urology,Huashan Hospital,Fudan University,Shanghai 200040,China

出　　处：《Asian Journal of Andrology》2020年第6期602-607,共6页亚洲男性学杂志（英文版）

基　　金：The authors would like to thank all patients involved in this study.This work was funded by the National Natural Science Foundation of China(No.81572531).The funding source provided financial support for the study and did not have any other involvement in this study.

摘　　要：The aims of this study were to determine the prog no stic value of primary tumor surgery and identify optimal can didates for such surgery among patients with semi noma and dista nt metastasis at diag no sis.We ide ntified 521 patients with seminoma and distant metastasis at diagnosis between 2004 and 2014 from the Surveillanee,Epidemiology,and End Results database.Among these patients,434 had undergone surgery,whereas 87 had not.The prognostic value of primary tumor surgery was assessed by Kaplan-Meier methods,log-rank analyses,and multivariate Cox's proportional hazards model.Survival curves and forest plots were also plotted.Survival analysis indicated that patients who underwent surgery had a better 5-year overall survival and cancer-specific survival tha n those who did not.Multivariate analyses dem on strated that primary tumor surgery is an in depende nt prog no stic factor for overall survival and cancer-specific survival,along with age at diagnosis,Mstage,and marital status.In addition,primary tumor surgery still had con siderable prog no stic value in the subgroup of patie nts with lymph node metastasis.Further,forest plots demonstrated that patie nts with Mia stage,N1 or N2-3 stage,and a youn ger age at diagnosis(<60 years)may ben efit from primary tumor surgery.In con elusion,our findings indicate that primary tumor surgery is correlated with improved survival in patients with seminoma and distant metastasis.Furthermore,primary tumor surgery is an independent prognostic indicator for patients with seminoma and distant metastasis.

关 键 词：distant metastasis primary tumor surgery PROGNOSIS SEMINOMA 

分 类 号：R699.8[医药卫生—泌尿科学]