Investigating the effect of pyroptosis on the slow CD4+T cell depletion in HIV-1 infection,by dynamical analysis of its discontinuous mathematical model  

作　　者：Z.Monfared F.Omidi Y.Qaseminezhad Raeini 

机构地区：[1]Department of Applied Mathematics Ferdowsi University of Mashhad(FUM),Mashhad,Iran [2]Department of Modem Science and Technology,Faculty of Medicine Mashhad University of Medical Sciences,Mashhad,Iran [3]Department of Mathematics Velayat University,Iranshahr,Iran [4]Department of Mathematics,Shahid Bahonar University of Kerman Kerman,Iran

出　　处：《International Journal of Biomathematics》2020年第6期53-75,共23页生物数学学报（英文版）

摘　　要：HIV infection is one of the most serious causes of death throughout the world.CD4+T cells which play an important role in immune protection,are the primary targets for HIV infection.The hallmark of HIV infection is the progressive loss in population of CD4+T cells.However,the pathway causing this slow T cell decline is poorly understood[16].This paper studies a discontinuous mathematical model for HIV-1 infection,to investigate the effect of pyroptosis on the disease.For this purpose,we use the theory of discontinuous dynamical systems.In this way,we can better analyze the dynamical behavior of the HIV-1 system.Especially,considering the dynamics of the system on its discontinuity boundary enables us to obtain more comprehensive results rather than the previous researches.A stability region for the system,corresponding to its equilibria on the discontinuity boundary,will be determined.In such a parametric region,the trajectories of the system will be trapped on the discontinuity manifold forever.It is also shown that in the obtained stability region,the disease can lead to a steady state in which the population of uninfected T cells and viruses will preserve at a constant level of cytokines.This means that the pyroptosis will be restricted and the disease cannot progress for a long time.Some numerical simulations based on clinical and experimental data are given which are in good agreement with our theoretical results.

关 键 词：HIV-1 infection CD4+T cell PYROPTOSIS discontinuous dynamical systems STABILITY 

分 类 号：R51[医药卫生—内科学]