类固醇激素治疗后手术切除与单纯类固醇治疗肉芽肿性小叶性乳腺炎的疗效对比分析  

Comparative Analysis of the Efficacy of Surgical Resection and Steroid Treatment for Granulomatous Lobular Mastitis after Steroid Therapy

作　　者：陈桂林[1] 陈丽娟[1] 黎润尧[2] 高学忠[1] CHEN Gui-lin;CHEN Li-juan;LI Run-yao;GAO Xue-zhong(Department of Breast Breast,Dongguan People's Hospital,Dongguan 511700,China;Department of Radiology,Dongguan People's Hospital,Dongguan 511700,China)

机构地区：[1]东莞市人民医院普济乳腺科,广东东莞511700 [2]东莞市人民医院放射科,广东东莞511700

出　　处：《药物生物技术》2020年第4期348-351,共4页Pharmaceutical Biotechnology

基　　金：东莞市社会科技发展项目(No.2018507150011329)。

摘　　要：探讨类固醇激素治疗后手术切除与单纯类固醇治疗肉芽肿性小叶性乳腺炎的疗效。选择2017年1月至2019年1月该院收治肉芽肿性小叶性乳腺炎女性患者60例纳入研究,按治疗方案不同分成研究组、对照组,各30例。对照组患者接受单纯类固醇激素治疗,研究组患者在类固醇激素治疗后开展手术切除治疗。观察两组治疗效果、复发率、乳房美容效果及治疗前、后血清炎症因子表达水平、乳房疼痛程度。研究组患者治疗总有效率100.00%(30/30)略高于对照组的86.67%(26/30),但差异无统计学意义(P>0.05);研究组患者复发率6.67%(2/30)低于对照组的23.33%(7/30)(P<0.05);研究组患者治疗后6个月乳房美容效果的优良率100.00%,高于对照组的76.67%(P<0.05);治疗7 d后,两组血清IL-6、TNF-α表达均降低,研究组低于对照组(P<0.05);两组患者治疗后7 d的乳房疼痛程度缓解,且研究组低于对照组(P<0.05)。类固醇激素治疗后手术切除与单纯类固醇治疗肉芽肿性小叶性乳腺炎均能获得显著疗效,但相较于单纯类固醇激素治疗,开展类固醇激素治疗后手术切除术能进一步降低患者复发风险,提高乳房美容效果,减轻机体炎症反应和乳房疼痛程度,具有良好应用价值。To investigate the efficacy of surgical resection and steroid treatment for granulomatous lobular mastitis after steroid therapy,from January 2017 to January 2019,60 cases of patients with granulomatous lobular mastitis were enrolled in the study.All patients were divided into study group and control group according to the treatment plan,30 cases in each group.The patients in the control group were received steroid therapy alone,and the patients in the study group were given surgical resection after steroid therapy.The therapeutic effects,recurrence rate,breast cosmetic effect,serum inflammatory factors and breast pain before and after treatment were observed.The total effective rate of treatment in the study group was 100.00%(30/30),which was slightly higher than that in the control group(86.67%,26/30)(P>0.05).The recurrence rate in the study group was 6.67%(2/30),which was lower than the control group(23.33%,7/30)(P<0.05).The excellent rate of breast cosmetic effect in the study group was 100.00%at6 months after treatment,which was higher than that in the control group(76.67%)(P<0.05).After 7 days of treatment,the expressions of serum IL-6 and TNF-αwere decreased in the two groups,and the study group was lower than those in the control group(P<0.05).The degree of breast pain was relieved 7 days after treatment in both groups,and the study group was lower than which in the control group(P<0.05).Surgical resection and steroid therapy for granulomatous lobular mastitis can achieve significant results,but compared with steroid therapy alone,surgical resection after steroid therapy can reduce the risk of recurrence and increase breast cosmetic effect.It also can reduce the body’s inflammatory response and breast pain.

关 键 词：类固醇激素 手术切除 肉芽肿性小叶性乳腺炎 复发率 疼痛程度 美容效果 炎症因子 

分 类 号：R737[医药卫生—肿瘤]