转录因子EB调控胰腺癌细胞自噬的研究进展  

Research Progress of Transcription Factor EB in Regulating Autophagy of Pancreatic Cancer Cells

作　　者：吴红 刘楠[1] WU Hong;LIU Nan(School of Life Science and Technology,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京211198

出　　处：《药物生物技术》2020年第4期385-389,共5页Pharmaceutical Biotechnology

摘　　要：胰腺癌因发现难、进展快、致死率高,被称为"癌中之王"。并且病人早期没有明显症状,一旦发现已处于癌症晚期,临床上缺少有效的治疗手段,更缺乏有效的靶向治疗药物,亟需发现有药可用的治疗靶点。转录因子EB(Transcription factor EB,TFEB)是一种具有亮氨酸拉链b HLH-LZ(Basic-helix-loop-helix leucine-zipper)结构的蛋白质,属于MIT-TFE转录因子家族。TFEB是调节自噬启动的转录因子之一,TFEB及其下游调控的多种基因组成了溶酶体协调表达和调控(Coordinated lysosomal expression and regulation)网络,在自噬溶酶体途径中发挥了重要功能。文章从MIT-TFE家族组成入手,重点阐述TFEB的结构、功能及其在肿瘤发生发展中的分子机制,为靶向自噬的胰腺癌治疗提供重要的理论依据。Pancreatic cancer is recognized as the‘king of cancers’since it is difficult to find,progresses quickly,and has a high mortality rate.The patient has no evident symptoms in the early stage until in the advanced stage.There is a lack of effective treatment methods in clinical practice,and there is also a lack of effective targeted therapeutic drugs,therefore it is urgent to find therapeutic targets that are available.Transcription factor EB is a protein with the structure of leucine zipper b HLH-LZ(basic-helixloop helix leucine-zipper),belonging to MIT-TFE transcription factor family.TFEB is one of the transcription factors that regulate autophagy initiation.TFEB and its downstream regulated genes form a coordinated lysosomal expression and regulation(CLEAR)network,which plays an important role in autolysosome pathway.This article will start from the composition of MIT-TFE family,focusing on the structure,function and molecular mechanism of TFEB in tumorigenesis and development,providing a crucial theoretical basis for the treatment of autophagy-targeted pancreatic cancer.

关 键 词：胰腺癌 自噬 MIT-TFE家族 转录因子EB 溶酶体协调表达和调控网络 自噬溶酶体 

分 类 号：R735.9[医药卫生—肿瘤]