非小细胞肺癌患者外周血及胸腔积液中Naa10p的表达情况及临床意义  

The expression and clinical significance of Naa10p in peripheral blood and pleural effusion of patients with non-small cell lung cancer

作　　者：胡鑫[1] 朱娜[1] 杨春燕[1] HU Xin;ZHU Na;YANG Chunyan(Department of Respiratory Medicine,PLA Lushan Rehabilitation and Recuperation Center,Jiangxi Jiujiang 332000,China)

机构地区：[1]中国人民解放军联勤保障部队庐山康复疗养中心呼吸内科,江西九江332000

出　　处：《现代肿瘤医学》2020年第23期4079-4083,共5页Journal of Modern Oncology

摘　　要：目的:探究非小细胞肺癌(NSCLC)患者外周血和胸腔积液中N端α位乙酰基转移酶10蛋白(Naa10p)的表达及临床意义。方法:选取2013年4月-2018年1月在本院住院的76例NSCLC合并胸腔积液患者作为试验组,选取同期在本院就诊的结核性胸膜炎患者63例为对照组,采集试验组及对照组的外周血和胸腔积液。采用酶联免疫法(ELISA)检测各组外周血和胸腔积液Naa10p表达情况;分析NSCLC患者外周血和胸腔积液Naa10p表达与临床病理参数的关系;分析NSCLC患者外周血和胸腔积液Naa10p表达对NSCLC患者生存情况的影响;Cox回归分析影响NSCLC的预后因素。结果:试验组外周血和胸腔积液中Naa10p表达明显高于对照组(P<0.05);NSCLC患者外周血和胸腔积液中Naa10p表达水平均与分化程度、N分期和M分期有关(P<0.05);绘制NSCLC患者化疗后12个月生存曲线,外周血和胸腔积液Naa10p高表达者的总生存率均明显低于低表达者(P<0.05);对外周血中Naa10p表达、胸腔积液中Naa10p表达、分化程度、N分期及M分期进行Cox回归分析,显示外周血中Naa10p表达、胸腔积液中Naa10p表达、N分期及M分期均是影响NSCLC预后的独立危险因素(P<0.05)。结论:NSCLC患者外周血和胸腔积液中的Naa10p均呈高表达,在不同部位的表达均与分化程度、N分期及M分期有关,外周血中和胸腔积液中Naa10p表达均是影响NSCLC预后的独立危险因素,且与患者预后密切相关,可为NSCLC的治疗提供参考。Objective:To investigate the expression and clinical significance of N-terminalαacetyltransferase 10 protein(Naa10 p)in peripheral blood and pleural effusion of patients with non-small cell lung cancer(NSCLC).Methods:76 patients with NSCLC complicated with pleural effusion hospitalized in our hospital from April 2013 to January 2018 were selected as the experimental group,and 63 patients with tuberculous pleurisy in our hospital at the same time were selected as the control group.Peripheral blood and pleural effusion were collected from the experimental group and the control group.The expression of Naa10 p in peripheral blood and pleural effusion was detected by enzyme-linked immunosorbent assay(ELISA).The relationships between the expressions of Naa10 p in peripheral blood and pleural effusion of NSCLC patients and clinicopathological parameters were analyzed.The influences of the expressions of Naa10 p in peripheral blood and pleural effusion of NSCLC patients on the survival of NSCLC patients were analyzed,and Cox regression analysis was used to analyze the effects of the prognostic factors of NSCLC.Results:The expression of Naa10 p in peripheral blood and pleural effusion in the experimental group was significantly higher than that in the control group(P<0.05).The expression of Naa10 p in peripheral blood and pleural effusion of patients with NSCLC was correlated with the degree of differentiation,N stage and M stage(P<0.05).The survival curve of NSCLC patients at 12 months after chemotherapy was drawn,and the overall survival rate of patients with high Naa10 p expression in peripheral blood and pleural effusion was significantly lower than that of patients with low Naa10 p expression(P<0.05).Cox regression analysis on the expression of Naa10 p in peripheral blood,the expression of Naa10 p in pleural effusion,differentiation degree,N stage and M stage showed that Naa10 p expression in peripheral blood,Naa10 p expression in pleural effusion,N stage and M stage were independent risk factors for the prognosis o

关 键 词：非小细胞肺癌 外周血 胸腔积液 N端α位乙酰基转移酶10蛋白 临床意义 

分 类 号：R734.2[医药卫生—肿瘤]