食源性镉暴露的肠道菌群毒性及维生素D对镉毒性保护作用研究进展  

Toxicity of foodborne cadmium exposure to gut microbiota and protective effect of vitamin D against the toxicity:a review of research progress

作　　者：蒋哲舜 巴乾[1] JIANG Zhe-shun;BA Qian(School of Public Health,Shanghai Jiao Tong University,Shanghai 200025,China)

机构地区：[1]上海交通大学公共卫生学院,上海200025

出　　处：《中国公共卫生》2020年第11期1661-1664,共4页Chinese Journal of Public Health

基　　金：国家自然科学基金(81573161);上海市卫生计生系统优秀青年医学人才培养计划(2017YQ059)。

摘　　要：肠道菌群是定植在人体肠道内并长期与人体相互依存的细菌群的总称,影响机体免疫功能、脂肪及能量代谢、内分泌功能等多方面进程。肠道菌群失衡会产生一系列潜在健康危害,并与多种慢性疾病的发生密切相关。外源物质包括有害污染物和营养成分,能通过肠道菌群影响健康。已有研究证明重金属镉暴露能明显扰乱小鼠肠道菌群的结构和组成,显著降低其中有益菌的数量;而维生素D能调节小鼠肠道菌群稳态,增加益生菌的数量,并能够影响小鼠对结肠炎的易感性。本文综述了镉、维生素D对肠道菌群的影响,探讨维生素D补充对预防和降低镉暴露所造成的肠道危害的可行性。Gut microbiota are a group of bacteria locating in human gut and are interdependent with human body for a long time.Gut microbiota affect body immune function,fat and energy metabolism,endocrine secretion and so forth.The imbalance of gut microbiota is closely related to the occurrence of many chronic diseases and could cause a series of potential health hazards.Exogenous substances,including harmful pollutants and nutrients,can affect health by influencing the intestinal flora.Studies have shown that cadmium exposure can remarkably disrupt the structure and number of gut microbiota,and significantly reduce the number of beneficial bacteria in mice;while vitamin D can regulate the gut microbiota and increase the number of probiotics,and it can change the susceptibility of mice to colitis.The study reviewed the effects of cadmium exposure and vitamin D deficiency or supplementation on gut microbiota,and discussed the feasibility of vitamin D supplementation to prevent and reduce the health hazards of cadmium exposure.

关 键 词：镉暴露 维生素D 肠道菌群 益生菌 

分 类 号：R114[医药卫生—卫生毒理学]