Transferrin receptor 1 plays an important role in muscle development and denervation-induced muscular atrophy  

作　　者：Ying Li Juan-Xian Cheng Hai-Hong Yang Li-Ping Chen Feng-Jiao Liu Yan Wu Ming Fan Hai-Tao Wu 

机构地区：[1]Department of Neurobiology,Beijing Institute of Basic Medical Sciences,Beijing,China [2]Department of Anesthesiology,the General Hospital of Western Theater Command,Chengdu,Sichuan Province,China [3]Chinese Institute for Brain Research(CIBR),Beijing,China [4]Key Laboratory of Neuroregeneration,Coinnovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China

出　　处：《Neural Regeneration Research》2021年第7期1308-1316,共9页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China, Nos.31770929(to HTW), 31522029(to HTW), 81902847(to HHY);the Beijing Municipal Science and Technology Commission of China, Nos.Z181100001518001(to HTW), Z161100000216154(to HTW)。

摘　　要：Previous studies demonstrate an accumulation of transferrin and transferrin receptor 1(TfR1) in regenerating peripheral nerves.However, the expression and function of transferrin and TfR1 in the denervated skeletal muscle remain poorly understood.In this study, a mouse model of denervation was produced by complete tear of the left brachial plexus nerve.RNA-sequencing revealed that transferrin expression in the denervated skeletal muscle was upregulated, while TfR1 expression was downregulated.We also investigated the function of TfR1 during development and in adult skeletal muscles in mice with inducible deletion or loss of TfR1.The ablation of TfR1 in skeletal muscle in early development caused severe muscular atrophy and early death.In comparison, deletion of TfR1 in adult skeletal muscles did not affect survival or glucose metabolism, but caused skeletal muscle atrophy and motor functional impairment, similar to the muscular atrophy phenotype observed after denervation.These findings suggest that TfR1 plays an important role in muscle development and denervation-induced muscular atrophy.This study was approved by the Institutional Animal Care and Use Committee of Beijing Institute of Basic Medical Sciences, China(approval No.SYXK 2017-C023) on June 1, 2018.

关 键 词：brachial plexus nerve INNERVATION iron motor dysfunction muscle atrophy signal skeletal muscle TRANSFERRIN 

分 类 号：R446[医药卫生—诊断学] R746[医药卫生—临床医学]