TRANSFERRIN

作品数：76被引量：139H指数：7
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相关机构：北京大学西北农林科技大学河南科技大学海安市人民医院更多>>
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Effects of acupuncture on iron metabolism in the hippocampus of the rats with cerebral ischemia-reperfusion injury based on the imbalance of iron homeostasis
《World Journal of Acupuncture-Moxibustion》2024年第4期292-299,共8页Hong-Juan WANG Hong TANG Shan-Shan JIANG Zhan-Fu LI Hao-mei TIAN Chu-Tao CHEN 
Supported by the Project of National Natural Science Fund of China:81874508,82274662;the Project of Natural Science Fund of Hunan Province:2021J304905;the Project of Natural Science Fund of Changsha Science and Technology Ministry of Hunan Province:kq2014094.
Objective:This study aimed to observe the effects of acupuncture on iron metabolism in the hippocampus of rats with cerebral ischemia-reperfusion injury(CIRI)and to explore the mechanism of acupuncture on neural repai...
关键词：ACUPUNCTURE Iron homeostasis Cerebral ischemia-reperfusion injury Ferroptosis TRANSFERRIN RATS 
Serum nutritional predictive biomarkers and risk assessment for anastomotic leakage after laparoscopic surgery in rectal cancer patients被引量：2
《World Journal of Gastrointestinal Surgery》2024年第10期3142-3154,共13页Paerhati Shayimu Maitisaidi Awula Chang-Yong Wang Rexida Jiapaer Yi-Peng Pan Zhi-Min Wu Yi Chen Ze-Liang Zhao 
Supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region,No.2019D01C261.
BACKGROUND Anastomotic leakage(AL)is one of the severest complications after laparoscopic surgery for middle/low rectal cancer,significantly impacting patient outcomes.Identifying reliable predictive factors for AL re...
关键词：Rectal cancer Laparoscopic operation Anastomotic leakage ALBUMIN PREALBUMIN TRANSFERRIN 
Utilizing dual-responsive iridium(Ⅲ) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy
《Chinese Chemical Letters》2024年第9期296-302,共7页Jinyu Guo Yandai Lin Shaohua He Yueqing Chen Fenglu Li Renjie Ruan Gaoxing Pan Hexin Nan Jibin Song Jin Zhang 
supported by the National Key R&D Program of China(Nos.2022YFB3808000,2022YFB3808001);the Project for High-Level Talent Innovation and Entrepreneurship of Quanzhou(No.2022C016R);the Medical Innovation Project of Science and Technology Program of Fujian Provincial Health Commission(No.2021CXA006);the Key Program of Qingyuan Innovation Laboratory(No.00221002).
Stimuli-triggered release and alleviating resistance of iridium(Ⅲ)-based drugs at tumor sites remains challengeable for clinical hepatoma therapy.Herein,a doxorubicin@iridium-transferrin(DOX@Ir-TF)nanovesicle was syn...
关键词：Amphiphilic iridium complex Transferrin targeting NIR/GSH dual-responsiveness Photoacoustic imaging Synergistic tumor therapy 
Transferrin Is Up-Regulated by Microbes and Acts as a Negative Regulator of Immunity to Induce Intestinal Immunotolerance
《Research》2024年第3期761-774,共14页Xiaopeng Tang Mingqian Fang Ruomei Cheng Junkun Niu Xiaoshan Huang Kuanhong Xu Gan Wang Yang Sun Zhiyi Liao Zhiye Zhang James Mwangi Qiumin Lu Aili Wang Longbao Lv Chao Liu Yinglei Miao Ren Lai 
the National Key Research and Development Program of China(2022YFF1301601);the Ministry of Science and Technology of China(2018YFA0801403 and 2022YFC2105003);the National Science Foundation of China(31930015,32100907,U2002219,and 32371162);the Chinese Academy of Sciences(KFJ-BRP-008 and SAJC202103);Yunnan Province(202003AD150008,202202AA100002 and 202301AS070074);the Kunming Science and Technology Bureau(2022SCP007);the New Cornerstone Investigator Program from Shenzhen New Cornerstone Science Foundation,Excellent Young Scientists Foundation of Shandong Province(ZR2023YQ025);the Frontiers Medical Center,Tianfu Jincheng Laboratory Foundation(TFJC2023010007);the PI Project of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(GML2021GD0807).
Cross-talks (e.g., host-driven iron withdrawal and microbial iron uptake between host gastrointestinal tract and commensal microbes) regulate immunotolerance and intestinal homeostasis. However, underlying mechanisms ...
关键词：IMPAIRED IMMUNITY tolerance 
A transferrin receptor targeting dual-modal MR/NIR fluorescent imaging probe for glioblastoma diagnosis
《Regenerative Biomaterials》2024年第3期122-133,共12页Jiaqi Hao Huawei Cai Lei Gu Yiqi Ma Yan Li Beibei Liu Hongyan Zhu Fanxin Zeng Min Wu 
the Scientific and Technological Achievements Transformation Fund of West China Hospital,Sichuan University(grant CGZH21002);the Innovative Research Project of Sichuan University(grant 2022SCUH00132);the Sichuan Foundation for Distinguished Young Scholars(grant 2022JDJQ0049).
The prognosis of glioblastoma(GBM)remains challenging,primarily due to the lack of a precise,effective imaging technique for comprehensively characterization.Addressing GBM diagnostic challenges,our study introduces a...
关键词：GLIOBLASTOMA magnetic resonance imaging dual-modal probes near-infrared fluorescent targeting peptides 
In situ autophagy regulation in synergy with phototherapy for breast cancer treatment被引量：1
《Acta Pharmaceutica Sinica B》2024年第5期2317-2332,共16页Huijuan Zhang Xiangyang Xuan Yaping Wang Zijun Qi Kexuan Cao Yingmei Tian Chaoqun Wang Junbiao Chang Zhenzhong Zhang Lin Hou 
This work was supported by the National Natural Science Foundation of China(Nos.82102918,81972893 and 82172719);the Key Program for Science and Technology Research in Henan Province(No.232102311093,China);the Training Plan for Young Backbone Teachers in Higher Education Institutions of Henan Province(No.2021ZDGGJS054,China).
Autophagy is an important factor in reducing the efficacy of tumor phototherapy(including PTT and PDT).Accurate regulation of autophagy in tumor cells is a new strategy to improve the anti-tumor efficiency of PTT/PDT....
关键词：AUTOPHAGY Tumor phototherapy Synergistic sensitization HCQ TRANSFERRIN Disulfide bond reconstruction GSH Biomimetic mineralized nano-tellurium 
Serum Iron Overload Activates the SMAD Pathway and Hepcidin Expression of Hepatocytes via SMURF1被引量：1
《Journal of Clinical and Translational Hepatology》2024年第3期227-235,共9页Ning Zhang Pengyao Yang Yanmeng Li Qin Ouyang Fei Hou Guixin Zhu Bei Zhang Jian Huang Jidong Jia Anjian Xu 
supported by the National Natural Science Foundation of China(No.82370898);Beijing Natural Science Foundation(No.7202034).
Background and Aims:Liver iron overload can induce hepatic expression of bone morphogenic protein(BMP)6 and activate the BMP/SMAD pathway.However,serum iron overload can also activate SMAD but does not induce BMP6 exp...
关键词：BMP/SMAD pathway HEPCIDIN Holo-transferrin Ubiquitin-proteasome degradation HEMOCHROMATOSIS 
CD71-mediated liposomal arsenic-nickel complex combined with all-trans retinoic acid for the efficacy of acute promyelocytic leukemia
《Asian Journal of Pharmaceutical Sciences》2023年第4期80-95,共16页Xiao Liu Lili Zhang Yueying Yang Weiwei Yin Yunhu Liu Chunyi Luo Ruizhe Zhang Zhiguo Long Yanyan Jiang Bing Wang 
supported by the Science and Technology Commission of Shanghai Municipality (20S11902600);the National Natural Science Foundation of China (82172615);the PDH-SPFDU Joint Research Fund (RHJJ2018-05)
Clinically,arsenic trioxide(ATO)was applied to the treatment of acute promyelocytic leukemia(APL)as a reliable and effective frontline drug.However,the administration regimen of AsⅢwas limited due to its fast clearan...
关键词：TRANSFERRIN Arsenic trioxide Acute promyelocytic leukemia All-trans retinoic acid LIPOSOME 
Transferrin-guided intelligent nanovesicles augment the targetability and potency of clinical PLK1 inhibitor to acute myeloid leukemia被引量：1
《Bioactive Materials》2023年第3期499-510,共12页Yifeng Xia Jingnan An Jiaying Li Wenxing Gu Yifan Zhang Songsong Zhao Cenzhu Zhao Yang Xu Bin Li Zhiyuan Zhong Fenghua Meng 
National Natural Science Foundation of China(NSFC 52033006 and 82000157);Natural Science Foundation of Jiangsu Province(NO.BK20190173).
Acute myeloid leukemia(AML)remains a most lethal hematological malignancy,partly because of its slow development of targeted therapies compared with other cancers.PLK1 inhibitor,volasertib(Vol),is among the few molecu...
关键词：Targeted delivery Acute myeloid leukemia Polo-like kinase 1 Molecular targeted drug 
Transferrin receptor 1 plays an important role in muscle development and denervation-induced muscular atrophy被引量：3
《Neural Regeneration Research》2021年第7期1308-1316,共9页Ying Li Juan-Xian Cheng Hai-Hong Yang Li-Ping Chen Feng-Jiao Liu Yan Wu Ming Fan Hai-Tao Wu 
supported by the National Natural Science Foundation of China, Nos.31770929(to HTW), 31522029(to HTW), 81902847(to HHY);the Beijing Municipal Science and Technology Commission of China, Nos.Z181100001518001(to HTW), Z161100000216154(to HTW)。
Previous studies demonstrate an accumulation of transferrin and transferrin receptor 1(TfR1) in regenerating peripheral nerves.However, the expression and function of transferrin and TfR1 in the denervated skeletal mu...
关键词：brachial plexus nerve INNERVATION iron motor dysfunction muscle atrophy signal skeletal muscle TRANSFERRIN 
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