A transferrin receptor targeting dual-modal MR/NIR fluorescent imaging probe for glioblastoma diagnosis  

作　　者：Jiaqi Hao Huawei Cai Lei Gu Yiqi Ma Yan Li Beibei Liu Hongyan Zhu Fanxin Zeng Min Wu 

机构地区：[1]Department of Radiology and Huaxi MR Research Center(HMRRC),Functional and Molecular Imaging Key Laboratory of Sichuan Province,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China [2]Research Unit of Psychoradiology,Chinese Academy of Medical Sciences,Chengdu,Sichuan 610041,China [3]Department of Nuclear Medicine&Laboratory of Clinical Nuclear Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China [4]State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China [5]Department of Clinical Research Center,Dazhou Central Hospital,Dazhou,Sichuan 635000,China

出　　处：《Regenerative Biomaterials》2024年第3期122-133,共12页再生生物材料（英文版）

基　　金：the Scientific and Technological Achievements Transformation Fund of West China Hospital,Sichuan University(grant CGZH21002);the Innovative Research Project of Sichuan University(grant 2022SCUH00132);the Sichuan Foundation for Distinguished Young Scholars(grant 2022JDJQ0049).

摘　　要：The prognosis of glioblastoma(GBM)remains challenging,primarily due to the lack of a precise,effective imaging technique for comprehensively characterization.Addressing GBM diagnostic challenges,our study introduces an innovative dual-modal imaging that merges near-infrared(NIR)fluorescent imaging with magnetic resonance imaging(MR).This method employs superparamagnetic iron oxide nanoparticies coated with NIR fluorescent dyes,specifically Cyanine 7,and targeted peptides.This synthetic probe facilitates MRI functionality through superparamagnetic iron oxide nanoparticles,provides NIR imaging capability via Cyanine 7 and enhances tumor targeting trough peptide interactions,offering a comprehensive diagnostic tool for GBM.Notably,the probe traverses the blood-brain barrier,targeting GBM in vivo via peptides,producing clear and discermible images in both modalities.Cytotoxicity and histopathology assessments confirm the probe's favorable safet profile.These findings suggest that the dual-modal MRINIR fluorescent imaging probe could revolutionize GBM prognosis and survival rate which can also be extended to other tumors type.

关 键 词：GLIOBLASTOMA magnetic resonance imaging dual-modal probes near-infrared fluorescent targeting peptides 

分 类 号：R739.41[医药卫生—肿瘤] TH77[医药卫生—临床医学]