药物离子导入技术在病毒性和细菌性角膜炎患者治疗中的应用  

Study on the therapeutic effect of drug ion implantation in patients with viral keratitis and bacterial keratitis

作　　者：卢兰芳[1] 翟建伟[1] 苏伟[1] 缪霜 何淑燕 Lu Lanfang;Zhai Jianwei;Su Wei;Miao Shuang;He Shuyan(Department of Ophthalmology,Guangxi Hechi People’s Hospital,Hechi,Guangxi,547000 China)

机构地区：[1]广西河池市人民医院眼科,547000

出　　处：《中华实验和临床病毒学杂志》2020年第5期532-536,共5页Chinese Journal of Experimental and Clinical Virology

基　　金：河池市科学研究与计划开发(河科B1717-10)。

摘　　要：目的探讨药物离子导入技术对病毒性或细菌性角膜炎患者治疗效果。方法选取2018年4月至2019年4月到我院眼科治疗病毒性角膜及细菌性角膜炎的患者各200例作为研究对象,通过双盲前瞻性随机对照的方法将患者均分为两组,即对照组给予药物进行常规治疗,试验组在对照组的基础之上,采用药物离子导入技术进行治疗。观察两组患者出院时疗效有效率,视力的治疗效果,住院时间,并发症发生率,半年复发率以及护理满意度。结果试验组的治疗有效率100%、视力治疗有效率100%、护理满意度93%,均显著高于对照组,(χ2=4.082,P=0.043;χ2=4.082,P=0.043;χ2=59.282,P<0.001)。试验组患者住院时间(8.93±1.69)d、住院费用(5627.12±482.34)元、半年复发率2%、并发症发生率4%,均显著低于对照组(t=6.522,P<0.001;t=10.985,P<0.001;χ2=5.674,P=0.017;χ2=10.010,P=0.002)。结论药物离子导入技术对治疗病毒性、细菌性角膜炎效果优于常规的药物治疗,且治疗操作较方便,无不良反应,是在眼科治疗中值得推广的一种治疗手段。Objective To explore the therapeutic effect of drug ion implantation on viral or bacterial keratitis.Methods A total of 200 patients with viral keratitis and another 200 patients with bacterial keratitis who were admitted to our hospital for ophthalmic treatment from April 2018 to April 2019 were selected as research subjects,through double-blind,prospective,randomized controlled method patients were divided into two groups,namely the control group given routine treatment,and drug treatment group cases were treated on the basis of the routine treatment with drug iontophoresis technology.The effective rate,visual acuity,length of stay,complication rate,half-year recurrence rate and nursing satisfaction were observed.Results The treatment effective rate of the experimental group was 100%,the effective rate of vision treatment was 100%,and the nursing satisfaction rate was 93%,which was significantly higher than that of the control group,(χ2=4.082,P=0.043;χ2=4.082,P=0.043;χ2=59.282,P<0.001).The duration of hospitalization of the patients in the experimental group(8.93±1.69)d,the cost of hospitalization(5627.12±482.34)yuan,the recurrence rate of half a year was 2%,and the incidence of complications was 4%,which was significantly lower than that of the control group(t=6.522,P=0.000;t=10.985,P<0.001;χ2=5.674,P=0.017;χ2=10.010,P=0.002).Conclusions Drug ion implantation technology wasbetter than conventional drug treatment in the treatment of viral and bacterial keratitis,and the treatment operation is more convenient,did not produce adverse reactions,is worth promoting in ophthalmic treatment as an optional treatment method.

关 键 词：药物离子导入技术 病毒性角膜炎 细菌性角膜炎 并发症 

分 类 号：R772.21[医药卫生—眼科]