影响卵巢上皮性癌手术加紫杉醇联合顺铂化疗疗效的相关临床病理因素分析  

Analysis of the clinical pathological factors of epithelial ovarian carcinoma based on the surgical treatment plus paclitaxel combined with cisplatin in chemotherapy

作　　者：刘晓敏 苏俊玲 杜洁 张龙 毛建英 LIU Xiaomin;SU Junling;DU Jie;ZHANG Long;MAO Jianying(Gynecology and Obstetrics Department,Inner Mongolia People's Hospital,Inner Mongolia Hohhot 010017,China;Division of Medical Sciences,Inner Mongolia Medical University,Inner Mongolia Hohhot 010010,China)

机构地区：[1]内蒙古自治区人民医院妇产科,内蒙古呼和浩特010017 [2]内蒙古医科大学医学科学部,内蒙古呼和浩特010010

出　　处：《现代肿瘤医学》2020年第24期4313-4317,共5页Journal of Modern Oncology

基　　金：内蒙古自然科学基金面上项目(编号:2017MS08110)。

摘　　要：目的:探讨影响卵巢上皮性癌手术加紫杉醇联合顺铂化疗疗效的相关临床病理因素。方法:选取2014年1月至2016年3月于我院行手术治疗加紫杉醇联合顺铂化疗的296例卵巢上皮性癌患者进行资料分析,对所有患者进行3~24个月的随访,采用Logistic回归方程计算,观察影响卵巢上皮性癌手术加紫杉醇联合顺铂化疗疗效的相关临床病理因素。结果:本组296例患者客观缓解率(objective response rate,ORR)为70.95%,疾病控制率达到86.15%,本组296例患者随访6个月时,生存率为82.77%(245/296),随访1年生存率为71.96%(213/296),随访2年生存率为58.78%(174/296)。本次将ORR视为有效,PD+SD为无效,对比两组间的临床资料发现,两组在组织学分级、手术病理分期、大网膜切除、肿瘤细胞减瘤术的理想程度方面差异有统计学意义(P<0.05),将上述有差异资料带入Logistic回归方程计算,发现组织学分级、手术病理分期、大网膜切除、肿瘤细胞减瘤术均是影响卵巢上皮性癌的危险因素。结论:影响卵巢上皮性癌手术加紫杉醇联合顺铂化疗疗效的相关临床病理因素较多,临床应根据患者的实际情况采取个体化治疗,手术过程中应尽可能做到彻底除瘤,延长患者生存期限。Objective:To discuss the relevant pathological factors of epithelial ovarian carcinoma based on the surgical treatment plus paclitaxel combined with cisplatin in chemotherapy.Methods:The clinical data about 296 epithelial ovarian carcinoma patients treated from January 2014 to March 2016 in our hospital were analyzed.Patients were followed for 3~24 months.The Logistic regression equation was used to analyze the relevant pathological factors of epithelial ovarian carcinoma.Results:The objective response rate(ORR)was 70.95%.The disease control rate was 86.15%.After 6 months of follow-up visits,the survival rate was 82.77%(245/296).After 1 year of follow-up visit,the survival rate was 71.96%(213/296).After 2 years of follow-up visit,the survival rate was 58.78%(174/296).In the study,ORR patients were deemed as effective group and PD+SD patients as invalid group.The clinical data of histological grading,pathological staging,resection of omentum majus and cytoreductive surgery of tumor cells between groups were significantly different(P<0.05).According to Logistic regression equation,the risk factors of epithelial ovarian carcinoma included histological grading,pathological staging,resection of omentum majus and cytoreductive surgery of tumor cells.Conclusion:There are multiple pathological factors of epithelial ovarian carcinoma.According to the patient's actual conditions,the personalized therapy shall be taken to completely remove the tumor and extend the survival time.

关 键 词：卵巢上皮性癌 手术 化疗 病理因素 

分 类 号：R737.31[医药卫生—肿瘤]