自身免疫性肝炎患者血清抗核抗体、肝肾微粒体抗体、抗髓过氧化物酶抗体、抗平滑肌抗体联合抗可溶性肝抗原抗体水平的变化及临床意义  

Changes and clinical significance of serum antinuclear antibody,liver and kidney microsomal antibody,anti-myeloperoxidase antibody,anti-smooth muscle antibody and anti-soluble liver antigen antibody levels in patients with autoimmune hepatitis

作　　者：漆阳红 QI Yang-hong(Department of Laboratory Medicine,the Second People′s Hospital of Pingxiang City,Jiangxi Province,Pingxiang337000,China)

机构地区：[1]江西省萍乡市第二人民医院检验科,江西萍乡337000

出　　处：《中国当代医药》2020年第32期161-164,共4页China Modern Medicine

基　　金：江西省萍乡市科技计划项目。

摘　　要：目的探讨自身免疫性肝炎患者血清抗核抗体(ANA)、肝肾微粒体抗体(LKM)、抗髓过氧化物酶抗体(PANCA)、抗平滑肌抗体(SMA)联合抗可溶性肝抗原抗体(SLA)水平的变化情况,并分析其临床意义。方法选取2019年12月~2020年2月在萍乡市第二人民医院接受治疗的30例自身免疫性肝炎患者作为观察组,并选取同期在本院治疗的30例慢性病毒性肝炎患者作为对照组,行常规健康体检的健康人群30例作为健康组。比较三组常规生化检验指标结果及血清ANA、SMA、PANCA、LKM、SLA检测阳性率。结果观察组及对照组患者的丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、直接胆红素(DBil)、总胆红素(TBil)水平高于健康组,差异有统计学意义(P<0.05);观察组患者的ALT、AST、DBil、TBil水平与对照组比较,差异无统计学意义(P>0.05)。观察组及对照组患者的血清ANA、SMA、PANCA、LKM、SLA检测阳性率高于健康组,差异有统计学意义(P<0.05);观察组患者的血清ANA、SMA检测阳性率高于对照组,差异有统计学意义(P<0.05);观察组患者的PANCA、LKM、SLA检测阳性率与对照组比较,差异无统计学意义(P>0.05)。结论自身免疫性肝病患者的血清ANA、SMA、PANCA、LKM、SLA水平均有明显变化,且各自对自身免疫性肝病均有一定阳性检出率,临床可考虑通过将各指标联合检测,指导早期自身免疫性肝病的检测,以提高检出率。Objective To investigate the changes and analyze the clinical significance of serum antinuclear antibody(ANA),liver and kidney microsomal antibody(LKM),anti-myeloperoxidase antibody(PANCA),anti-smooth muscle antibody(SMA)and anti-soluble liver antigen antibody(SLA)in patients with autoimmune hepatitis.Methods A total of 30 patients with autoimmune hepatitis who treated in the Second People′s Hospital of Pingxiang City from December 2019 to February 2020 were selected as the observation group,and 30 patients with chronic viral hepatitis treated in this hospital were selected as the control group,30 healthy people who undergo routine health checks were selected as the health group.The serum ANA,SMA,PANCA,LKM and SLA test and routine biochemical test results were compared among three groups.Results The alanine aminotransferase(ALT),alanine aminotransferase(AST),direct bilirubin(DBil)and total bilirubin(TBil)of the observation group and the control group were higher than those of the health group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in ALT,AST,DBil and TBil between the control group and the observation group(P>0.05).The positive rates of serum ANA,LKM,PANCA,SMA,SLA in the observation group and the control group were higher than those of the health group,and the differences were statistically significant(P<0.05).The positive rates of serum ANA,SMA of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in the positive rates of PANCA,LKM,SLA between the observation group and the control group(P>0.05).Conclusion The serum ANA,LKM,PANCA,SMA,SLA level of patients with autoimmune liver disease has obvious changes,and has certain positive detection rate for autoimmune liver disease.In clinical practice,it can guide the detection of early autoimmune liver disease through the combined detection of all indicators,so as to improve

关 键 词：自身免疫性肝炎 抗核抗体 生化指标 

分 类 号：R575.1[医药卫生—消化系统]