雌激素受体在女性食管鳞状细胞癌中的表达及其与患者婚育因素和预后的关系  

Expression of estrogen receptor in female patients with esophageal squamous cell carcinoma and its relationship with marriage and childbearing factors and prognosis

作　　者：刘玉[1] 张冬云[2] 马凤巧[2] 易英杰 Liu Yu;Zhang Dongyun;Ma Fengqiao;Yi Yingjie(Department of Digestive Internal Medicine,Nanyang Center Hospital in Henan Province,Nanyang 473061,China;Department of Basic Medicine,Nanyang Medical College,Nanyang 473061,China)

机构地区：[1]河南省南阳市中心医院消化内科,473061 [2]南阳医学高等专科学校基础医学部,河南南阳473061

出　　处：《肿瘤研究与临床》2020年第10期685-689,共5页Cancer Research and Clinic

基　　金：河南省教育厅高等学校重点科研项目(20B320011);南阳医学高等专科学校博士基金(2015NYYZBSJJ01);河南省科技厅科技攻关项目(202102310366)。

摘　　要：目的探讨雌激素受体α(ERα)、雌激素受体β(ERβ)在中国女性食管鳞状细胞癌(ESCC)中的表达及其与患者临床病理特征、婚育因素的关系和对预后的影响。方法选取河南省南阳市中心医院2001年1月至2016年12月女性原发性ESCC患者110例。免疫组织化学法(IHC)检测ESCC组织中ERα、ERβ蛋白表达水平。logistic回归分析ERα、ERβ表达与患者婚育因素(经期状态、初潮年龄、初次生育年龄、妊娠次数)及临床病理特征(肿瘤部位、肿瘤浸润深度、有无淋巴结转移、肿瘤分期)的关系;Kaplan-Meier法进行生存分析,并行log-rank检验;Cox比例风险模型进行多因素生存分析。结果ERα、ERβ蛋白在女性ESCC组织中阳性表达率为37.3%(41/110)、64.5%(71/110)。ERβ表达与肿瘤部位(χ^2=6.999,P=0.030)、肿瘤分期(χ^2=11.097,P<0.01)和妊娠次数(χ^2=6.304,P=0.012)有关。妊娠次数>3次(HR=2.553,95%CI 1.051~6.203,P=0.039)、ERβ阳性(HR=2.580,95%CI 1.966~3.386,P<0.01)是患者生存独立保护因素;ERα阳性(HR=0.530,95%CI 0.384~0.739,P<0.01)、淋巴结转移(HR=0.663,95%CI 0.512~0.858,P=0.002)是患者生存独立危险因素。结论ERα和ERβ表达可预测女性ESCC患者预后。Objective To explore the expressions of estrogen receptorα(ERα)and estrogen receptor β(ERβ)in Chinese female esophageal squamous cell carcinoma(ESCC)and their relationship with clinical pathological characteristics,marriage and childbearing factors and their prognostic impact.Methods A total of 110 female patients with primary ESCC in Nanyang Center Hospital from January 2001 to December 2016 were selected.The expression levels of ERα and ERβ proteins were examined by immunohistochemistry(IHC).Logistic regression was used to analyze the correlations of ERα and ERβ expressions with marriage and childbearing factors(menstrual status,age of menarche,age of first birth and the number of pregnancy)and clinical pathological parameters(tumor location,tumor invasion depth,lymph node metastasis and tumor stage).Kaplan-Meier method was used for survival analysis and log-rank test was used.Cox proportional hazard model was used for survival multivariate analysis.Results The expression rates of ERαand ERβproteins were 37.3%(41/110)and 64.5%(71/110)in tissues of female ESCC patients,respectively.ERβexpression was closely correlated with tumor location(χ^2=0.999,P=0.030),tumor stage(χ^2=11.097,P<0.01)and the number of pregnancy(χ^2=6.304,P=0.012).The number of pregnancy(HR=2.553,95%CI 1.051-6.203,P=0.039)and ERβexpression(HR=2.580,95%CI 1.966-3.386,P<0.01)were independent protective factors for the survival of patients.Furthermore,ERαexpression(HR=0.530,95%CI 0.384-0.739,P<0.01)and lymph node metastasis(HR=0.663,95%CI 0.512-0.858,P=0.002)were independent risk factors for survival.Conclusion ERαand ERβ expressions can predict the prognosis of female ESCC patients.

关 键 词：食管肿瘤 癌 鳞状细胞 雌激素受体Α 雌激素受体Β 预后 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]