直肠癌患者BRMS1mRNA、PTNmRNA的表达及临床意义  

Expression and clinical significance of BRMS1mRNA and PTNmRNA in patients with rectal cancer

作　　者：马欢[1] 焦英华[1] 李曙光[2] 张贤雨[1] 魏玉磊[3] 田桂英[1] 卢秀荣[1] 原娜[1] MA Huan;JIAO Yinghua;LI Shuguang;ZHANG Xianyu;WEI Yulei;TIAN Guiying;LU Xiurong;YUAN Na(Department of Radiotherapy,the First Affiliated Hospital of Hebei North University,Zhangjiakou,He-bei,China,075000;Department of Gastrointestinal Oncology Surgery,the First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,China,075000;Department of Thoracic Surgery,the First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,China,075000)

机构地区：[1]河北北方学院附属第一医院放疗科,河北张家口075000 [2]河北北方学院附属第一医院胃肠肿瘤外科,河北张家口075000 [3]河北北方学院附属第一医院胸外科,河北张家口075000

出　　处：《分子诊断与治疗杂志》2020年第11期1479-1483,共5页Journal of Molecular Diagnostics and Therapy

基　　金：张家口市科技攻关计划项目(1321064D)。

摘　　要：目的研究乳腺癌转移抑制基因(BRMS1)及多效生长因子(PTN)在直肠癌患者的表达情况及其与病理参数、预后的关系。方法选取2016年1月至2017年5月本院收治的73例直肠癌患者临床资料,收集肿瘤组织及肿瘤旁(距离直肠癌组织5 cm以上)的正常直肠粘膜组织,分别作为直肠癌组(n=73)和癌旁组(n=73)。采用多元Logistic回归分析影响直肠癌患者预后生存的危险因素,绘制Kaplan-Meier生存曲线研究BRMS1mRNA、PTNmRNA对患者预后生存的影响。结果直肠癌组BRMS1mRNA表达水平较癌旁正常组织低,PTNmRNA阳性率较癌旁正常组织高,差异均具有统计学意义(P<0.05)。组织高分化、淋巴结无转移、Ⅰ+Ⅱ期、无血性转移、浸润深度未及浆膜、肿瘤距肛缘距离≤7 cm者BRMS1mRNA表达水平较组织中低分化、淋巴结转移、Ⅲ+Ⅳ期、血性转移、浸润深度达浆膜、肿瘤距肛缘距离>7 cm者高,PTNmRNA阳性率水平较组织中低分化、淋巴结转移、Ⅲ+Ⅳ期、血性转移、浸润深度达浆膜、肿瘤距肛缘距离>7 cm者低,差异均具有统计学意义(P<0.05)。组织中低分化、浸及浆膜、TNM分期:Ⅲ+Ⅳ期、淋巴结转移、BRMS1mRNA低表达及PTNmRNA阳性表达为影响直肠癌患者预后生存的独立危险因素(P<0.05)。BRMS1mRNA高表达组平均生存时间长于低表达组,差异具有统计学意义(P<0.05)。结论 BRMS1mRNA、PTNmRNA在直肠癌患者中呈异常状态,并与患者预后生存关系密切,可作为预测直肠癌患者预后生存的分子标志物和肿瘤治疗的潜在的靶点。Objective To study the expression of breast cancer metastasis suppressor(BRMS1 and Pleiotrophin(PTN)in patients with rectal cancer,and their relationship with pathological parameters and prognosis.Methods The clinical data of 73 patients with rectal cancer admitted to our hospital from January2016 to May 2017 were selected.The tumor tissue and the normal rectal mucosa tissue adjacent to the tumor(more than 5 cm from the rectal cancer tissue)were collected as the rectal cancer tissue group(n=73)and the adjacent normal tissue group(n=73).Multivariate Logistic regression was used to analyze the risk factors that affect the prognosis of patients with rectal cancer.Kaplan-Meier survival curve was drawn to study the effect of BRMS1 mRNA and PTNmRNA on the prognosis of patients.Results The expression level of BRMS1 mRNA in the rectal cancer tissue group was lower than that in the normal tissues adjacent to the cancer,and the positive rate of PTNmRNA was higher than that of the normal tissues adjacent to the cancer,the differences are statistically significant(P<0.05).The expression level of BRMS1 mRNA in patients who had well-differentiated tissues,no lymph node metastasis,were at stageⅠ+Ⅱ,no blood metastasis,and whose infiltration depth did not involve the serosal membrane,and tumor distance from anal margin was≤7 cm was higher than that of patients who had medium and low differentiated tissue,lymph node metastasis,bloody metastasis,and were stageⅢ+Ⅳ,and whose infiltration depth involved the serosal membrane,and tumor distance from anal margin was>7 cm,the differences are statistically significant(P<0.05).Poor differentiation in tissues,serosal infiltration and TNM staging:stageⅢ+Ⅳ,lymph node metastasis,low expression of BRMS1 RNA and positive expression of PTNmRNA were independent risk factors affecting the prognosis and survival of patients with rectal cancer(P<0.05).The average survival time of the BRMS1 mRNA high expression group was longer than that of the low expression group,the differences are sta

关 键 词：直肠癌 BRMS1 PTN 病理参数 

分 类 号：R735.37[医药卫生—肿瘤]