CIP2A、VCAM-1及TRF1在脑胶质瘤中的表达及临床意义  

Expressions and clinical significance of CIP2A,VCAM-1 and TRF1 in glioma

作　　者：董留建 王树凯[2] 冯书彬 冯强[2] 吕强 李涛[2] 裴航 齐林[2] DONG Liujian;WANG Shukai;FENG Shubin;FENG Qiang;LV Qiang;LI Tao;PEI Hang;QI Lin(Department of Neurosurgery,Henan children's Hospital(Zhengzhou children's Hospital);The First Affili-ated Hospital of Zhengzhou University)

机构地区：[1]河南省儿童医院(郑州儿童医院)神经外科,河南郑州450018 [2]郑州大学第一附属医院神经外科,河南郑州450018

出　　处：《分子诊断与治疗杂志》2020年第11期1570-1573,1577,共5页Journal of Molecular Diagnostics and Therapy

基　　金：河南省科技攻关计划(2017020202)。

摘　　要：目的分析蛋白磷酸酶2A的癌性抑制因子(CIP2A)、血管细胞黏附分子-1(VCAM-1)及端粒结合蛋白-1(TRF1)在脑胶质瘤中的表达及临床意义。方法收集本院2016年3月至2018年4月收治的77例脑胶质瘤患者脑组织标本(脑胶质瘤组)。同期选取50例非肿瘤患者颅脑外伤行减压而切除的脑组织标本作为对照组。比较2组CIP2A、VCAM-1及TRF1表达情况,分析CIP2A、VCAM-1及TRF1表达与脑胶质瘤临床病理特征的关系;采用多元Logistic回归分析影响脑胶质瘤患者预后死亡的独立危险因素。结果对照组CIP2A、VCAM-1阳性表达率显著低于脑胶质瘤组,TRF1阳性表达率显著高于脑胶质瘤组,差异均具有统计学意义(P<0.05)。低分级脑胶质瘤者CIP2A、VCAM-1阳性表达率明显低于高级别脑胶质瘤者,TRF1阳性表达率明显高于高级别脑胶质瘤者,差异均具有统计学意义(P<0.05)。经非条件多因素logistic回归模型分析结果显示:年龄(>45岁)、病理分级(高级别)、CIP2A(阳性)和VCAM-1(阳性)、TRF1(阴性)影响是脑胶质瘤患者预后死亡的独立危险因素(P<0.05)。结论 CIP2A、VCAM-1及TRF1在脑胶质瘤中的表达与其病理分级有关,可作为判断脑胶质瘤恶性程度及评估其预后的参考指标。Objective To analyze the expression and clinical significance of cancerous inhibitor of protein phosphatase 2 A(CIP2 A),vascular cell adhesion molecule-1(VCAM-1)and telomere repeat binding-1 factor-1(TRF1)in glioma.Method The brain tissue specimentsof 77 patients with glioma who were admitted to our hospital from March 2016 to April 2018 were collected(glioma group).At the same time,50 brain specimens of non-tumor patients with craniocerebral trauma underwent decompression and resection were selected as the control group.The expressions of CIP2 A,VCAM-1 and TRF1 between the two groups were compared,and the relationship between the expressions of CIP2 A,VCAM-1 and TRF1 and the clinicopathological characteristics of glioma was analyzed.Multiple logistic regression was used to analyze the independent risk factors affecting the death prognosis of patients with glioma.Results The positive expression rate of CIP2 A and VCAM-1 in the control group was significantly lower than that in the glioma group,and the positive expression rate of TRF1 was significantly higher than that in the glioma group,and differences are statistically significant(P<0.05).The positive expression rate of CIP2 A and VCAM-1 in patients with low-grade gliomas was significantly lower than those in patients with high-grade gliomas,and the positive expression rate of TRF1 was significantly higher than that in patients with high-grade gliomas,and differences are statistically significant P<0.05).The results of unconditional multivariate logistic regression model analysis show that:age(>45 years old),pathological grade(high grade),CIP2 A(positive)and VCAM-1(positive),TRF1(negative)are independent risk factors that affect the death prognosis of patients with glioma(P<0.05).Conclusion The expression of CIP2 A,VCAM-1 and TRF1 in gliomas is related to its pathological grade,andcan be used as a reference index for judging the malignant degree of gliomas and evaluating its prognosis.

关 键 词：蛋白磷酸酶2A的癌性抑制因子 血管细胞黏附分子-1 端粒结合蛋白-1 脑胶质瘤 

分 类 号：R739.41[医药卫生—肿瘤]