化疗序贯放射性125I粒子植入治疗局部晚期非小细胞肺癌临床研究  

Clinical study of sequential radioactive I seed implantation in the treatment of locally advanced non-small cell lung cancer

作　　者：杜俊良 赵月妹 赵文香 刘淑真[2] 于国华[2] DU Junliang;ZHAO Yuemei;ZHAO Wenxiang;LIU Shuzhen;YU Guohua(Department,of Oncology Laboratory,Weifang Medical University,Weifang 261053,Chirui;Department of Oncology,Wcifarig People's Hospital)

机构地区：[1]潍坊医学院肿瘤学教研室,山东潍坊261053 [2]潍坊市人民医院肿瘤内科

出　　处：《潍坊医学院学报》2020年第4期252-254,共3页Acta Academiae Medicinae Weifang

摘　　要：目的观察化疗序贯放射性125I粒子植入治疗局部晚期非小细胞肺癌的临床疗效。方法选取潍坊市人民医院肿瘤内科在2016年10月~2019年9月期间收治的42例非小细胞肺癌患者作为研究对象进行回顾性研究。根据治疗方式分为观察组和对照组,各21例。观察组给予化疗序贯放射性125I粒子植入治疗,对照组则给予化疗同步放射性125I粒子植入治疗,通过Kaplan-Meier法进行生存分析,研究终点为无进展生存期(PFS),采用Log-rank检验比较无进展生存率。结果观察组18个月PFS率为57.1%(12/21),对照组PFS率为9.5%(2/21),两组比较,差异有显著性(P<0.05)。观察组中位PFS为19.0个月,对照组中位PFS为11.0个月,两组比较,差异有显著性(P<0.05)。结论化疗序贯放射性125I粒子植入治疗局部晚期非小细胞肺癌的疗效明显优于化疗同步放射性125I粒子植入治疗。Objective To observe the clinical efficacy of sequential radioactive 125I seed implantation in the treatment of locally advanced non-small cell lung cancer.Methods A retrospective study was performed on 42 patients with non-small cell lung cancer who were treated by the Department of Oncology of Weifang People’s Hospital from October 2016 to September 2019.According to the treatment method,21 cases were divided into observation group and control group.The observation group was treated with sequential radioactive 125I seed implantation for chemotherapy,while the control group was given chemotherapy concurrent radioactive 125I particle implantation.Median progression free survival(PFS) time of the two groups were compared by Kaplan-Meier analysis.The difference of progression free survival between the two groups was analyzed by log-rank method.Results The PFS rate of 18 months in the observation group was 57.1%(12/21),and the PFS rate of 18 months in the control group was 9.5%(2/21),there was significant difference between the two groups(P<0.05).Comparing the median PFS of the two groups,the median PFS of the observation group was 19.0 months,and the median PFS of the control group was 11.0 months,there was significant difference between the two groups(P<0.05).Conclusion The effect of sequential radioactive 125I seed implantation for chemotherapy in the treatment of locally advanced non-small cell lung cancer is significantly better than that of concurrent radioactive 125I seed implantation for chemotherapy.

关 键 词：放射性125I粒子 化疗 序贯 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]