疣状角化不良瘤8例临床及组织病理分析  

Clinicopathological analysis of eight cases of warty dyskeratoma

作　　者：沈慧 吴飞 徐明园 刘业强 SHEN Hui;WU Fei;XU Ming-yuan;LIU Ye-qiang(Department of Dermatology,the First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,China)

机构地区：[1]湖南中医药大学第一附属医院皮肤科,湖南长沙410007 [2]上海市皮肤病医院皮肤病理科,上海200433

出　　处：《临床皮肤科杂志》2020年第11期647-649,共3页Journal of Clinical Dermatology

摘　　要：目的:探讨疣状角化不良瘤的临床组织病理特征、诊断及鉴别诊断。方法:收集2015年1月—2019年7月上海市皮肤病医院病理科诊断为疣状角化不良瘤的8例患者,对其临床资料进行回顾性分析。结果:8例疣状角化不良瘤患者,病因不清,年龄25~85岁,平均(51.4±21.9)岁。8例患者中4例皮损位于头面部;2例位于大腿;1例位于胸部;1例位于肛周。临床表现均为0.2~1.0 cm的肤色或褐色丘疹、结节,无特殊不适。8例患者的组织病理学表现为1个或多个与毛囊相关的高度扩张的杯状、结节状或囊状的皮损,其内充满角蛋白碎片,相邻及深层表皮伴有显著的棘层松解,附近可见圆体和谷粒。结论:疣状角化不良瘤是一种少见的皮肤良性肿瘤,临床诊断困难,多依赖于组织病理诊断。该病治疗以手术切除为主,随访均无复发。Objective: To investigate the clinicopathological features, diagnosis and differential diagnosis of warty dyskeratoma.Methods:Eight cases of warty dyskeratoma diagnosed in the Pathology Department of Shanghai Dermatology Hospital from January2015 to July 2019 were retrospectively analyzed. Result: Eight patients of warty dyskeratoma had unclear etiologies, with an average age of 51.4±21.9 years old. Among the 8 patients, 4 cases were on the head and face, 2 cases on the thigh, 1 case on the chest, and 1 case was located around the anus. The clinical manifestations were all 0.2~1.0 cm skin color or brown papules and nodules without special discomfort. Histopathological examination revealed one or more highly dilated cup-shaped, nodular or cystic skin lesions related to hair follicles, which were filled with keratin fragments, and adjacent and deep epidermis were accompanied. The spinous layer was loosened, and rounded bodies and grains could be seen nearby. Conclusion: Warty dyskeratoma is a rare benign skin tumor. The clinical diagnosis of it is difficult and depends on pathological diagnosis. Surgical resection is commonly adopted to treat it, and no recurrence is found during follow-up in all cases.

关 键 词：疣状角化不良瘤 

分 类 号：R739.5[医药卫生—肿瘤]