合成大麻素类新精神活性物质5F-MDMB-PICA的检验  

Identifying 5F-MDMB-PICA,One Synthetic Cannabinoid of New Psychoactive Substance from Seized Samples

作　　者：王跨陡 袁晓亮 张玉荣[1] 刘文斌 胡钧健 曹芳琦 邹芸 WANG Kuadou;YUAN Xiaoliang;ZHANG Yurong;LIU Wenbin;HU Junjian;CAO Fangqi;ZOU Yun(Identifi cation Center of Evidential Materials,Shanghai 200083,China;Academy of Criminal Science and Technology,Shanghai Public Security Bureau,Shanghai 200083,China)

机构地区：[1]上海市公安局物证鉴定中心,上海200083 [2]上海市刑事科学技术研究院,上海200083

出　　处：《刑事技术》2020年第6期591-596,共6页Forensic Science and Technology

基　　金：国家自然科学基金青年科学基金项目(81701864);上海市优秀学术带头人计划资助(19XD1432700);上海市青年科技启明星计划资助(18QB1403400);上海市自然科学基金探索类项目(17ZR1441600)。

摘　　要：目的建立基于红外光谱(FT-IR)、气相色谱-质谱(GC-MS)、高分辨质谱(high resolution mass spectrometer,HRMS)、核磁共振波谱(nuclear magnetic resonance spectroscopy,NMR)等多技术联合检验合成大麻素类新精神活性物质5F-MDMB-PICA的方法。方法粉末样品直接用FT-IR检测;粉末样品用甲醇溶解、烟丝样品用甲醇提取后采用GC-MS和高分辨质谱检测;粉末样品用氘代甲醇溶解后进行核磁共振氢谱(1H NMR)结构确证。结果GC-MS检测测得样品中主要组分的质谱特征离子(m/z)为232(基峰)、144、376、320、288、260、116、212,HRMS实测的精确质量数[M+H]+为377.22305,经数据库检索比对再结合数据分析,并经1H NMR确证,确定了该样品为5F-MDMB-PICA。而且,样品中主要组分的GC-MS保留时间和特征离子与5F-MDMB-PICA对照品一致。结论本研究建立的方法快速、简便、准确,可用于样品中5F-MDMB-PICA的检验,同时可为其他合成大麻素类新精神活性物质的检验提供方法参考。5F-MDMB-PICA(chemical designation:methyl 2-[[1-(5-fl uoropentyl)indole-3-carbonyl]amino]-3,3-dimethylbutanoate),a new psychoactive substance of synthetic cannabinoid,was identifi ed through the analytic approaches of FT-IR,GC-MS,LC-MS and NMR,thereby having a multiple-technic-combinatorial qualitative detection and differentiation method established for such a substance from several evidential materials(powder and tobacco).For the sample of powder,FT-IR was adopted to test it,yet getting a low match from its spectrum repertory which to query with the tested result(guessing the low purity of the sample to cause it).Whereas,both the powder and tobacco-thread samples gave positive result from either GCMS or LC-MS analysis after appropriate and necessary treatments being imposed into the sample,resulting the sample in GCMS rendering main-constituent mass spectral characteristic ions(m/z)at 232(base peak),144,376,320,288,260,116,212.Further,LC-MS(one kind of HRMS-high resolution mass spectrometer)revealed the targeted chemical is of precise mass quantity[M+H]+as 377.22305.Even,NMR detection confi rmed the structure of the chemical from the powder sample that was previously dissolved with deuterated methanol to undergo the 1H-NMR parsing.With all the tested results and those from querying the involving database to bring into a conclusion altogether,the chemical is no doubt 5F-MDMB-PICA.Prominently,NMR approach proved its great potential for chemical structure acquisition of unknown compounds(e.g.,the here-concerned new psychoactive substances),meanwhile demonstrating its unique advantages of high visibility,effi ciency and credibility.

关 键 词：法医毒物学 合成大麻素 5F-MDMB-PICA 气相色谱-质谱联用 高分辨质谱 核磁共振 

分 类 号：DF795.1[医药卫生—法医学]