血清sCD40L和CD146与急性缺血性脑卒中后局部血流灌注患者预后的相关性  

Correlation between serum sCD40L,CD146 and prognosis of patients with regional blood perfusion after cerebral ischemic stroke

作　　者：赖琼 赵晓玲[1] 李立[1] 周咏梅[1] 刘艳[1] LAI Qiong;ZHAO Xiaoling;LI Li;ZHOU Yongmei;LIU Yan(Department of Neurology, Chengdu Third People's Hospital, Chengdu 610031, China)

机构地区：[1]成都市第三人民医院神经内科,四川成都610031

出　　处：《西部医学》2020年第11期1673-1676,共4页Medical Journal of West China

摘　　要：目的探究血清可溶性CD40配体(sCD40L)、CD146与急性缺血性脑卒中(CIS)后局部血流灌注患者预后的相关性。方法选取2017年1月~2019年12月我院收治的102例CIS患者依据影像学检查结果分为低灌注组(局部血流低灌注)、对照组(局部血流无灌注),依据随访结果将低灌注组患者分为预后良好组与预后不良亚组。对比低灌注组和对照组一般资料、实验室指标、血清sCD40L、mRS评分、CD146水平。单因素和二元Logistic回归分析影响CIS后局部血流灌注患者预后的高危因素,Spearman相关分析血清sCD40L、CD146水平与CIS后局部血流灌注患者预后的关系。结果影像学检查发现102例患者中56例存在局部血流灌注(54.90%),其中低灌注组sCD40L、mRS评分均高于对照组,CD146水平明显低于对照组(P<0.05)。56例CIS后局部血流灌注患者随访结果显示,预后良好者9例,预后不良者47例,预后不良者年龄≥60岁、LDLC、sCD40L较预后良好者明显高,TC、HDLC、CD146较预后良好组明显低(P<0.05)。二元Logistic回归分析显示,sCD40L、CD146水平是CIS后局部血流灌注患者预后的高危因素(P<0.05)。Spearman相关分析显示,CIS后局部血流灌注患者血清sCD40L水平与预后呈负相关,而CD146水平与预后呈正相关(P<0.05)。结论血清sCD40L、CD146水平是影响CIS后局部血流灌注患者预后的高危因素,其检测结果可作为CIS后局部血流灌注患者预后的有效预测指标。Objective To investigate the correlation between serum soluble CD40 ligand(sCD40L),CD146 and prognosis of patients with regional blood perfusion after cerebral ischemic stroke(CIS).Methods 102 patients with CIS admitted to the hospital between January 2017 and December 2019 were selected as subjects.They were divided into the hypoperfusion group(regional hypoperfusion)and the control group(regional blood flow no perfusion)according to the imaging examination results.Patients in the hypoperfusion group were divided into the good prognosis group and the poor prognosis group according to the follow-up results.General data,laboratory indicators,serum sCD40L and CD146 levels in the hypoperfusion group and the control group were compared.Univariate and bivariate Logistic regression analyses were conducted to analyze the risk factors influencing the prognosis of patients with regional blood perfusion after CIS.Spearman correlation analysis was performed to analyze the relationship between serum sCD40L and CD146 levels and the prognosis of patients with regional blood perfusion after CIS.Results Of the 102 patients,56(54.90%)with regional blood perfusion were found by imaging examination.The sCD40L and mRS scores in the hypoperfusion group were significantly higher than those in the control group but CD146 levels were significantly lower than the control group(P<0.05).The follow-up results of 56 patients with local blood perfusion after CIS showed that 9 patients had good prognosis and 47 patients had poor prognosis.The proportions of patients≥60 years old,LDLC and sCD40L in the poor prognosis group were significantly higher than those in the good prognosis group.However,TC,HDLC and CD146 were significantly lower than the good prognosis group(P<0.05).Bivariate Logistic regression analysis showed that sCD40L and CD146 levels were high risk factors for prognosis of patients with local blood perfusion after CIS(P<0.05).Spearman correlation analysis showed that serum sCD40L levels in patients with local blood perfusion aft

关 键 词：急性缺血性脑卒中 SCD40L CD146 血流灌注 预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]