转化生长因子-β信号通路与结直肠癌关系的研究进展  

Relationship of transforming growth factor-βsignaling with colorectal cancer

作　　者：王松[1] 葛步军[1] 黄琦[1] WANG Song;GE Bujun;HUANG Qi(Department of General Surgery,Shanghai Tongji Hospital,Tongji Hospital Affiliated to Tongji University,Shanghai 200065,China)

机构地区：[1]同济大学附属同济医院上海市同济医院普外科,上海200065

出　　处：《中华实用诊断与治疗杂志》2020年第11期1178-1180,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家自然基金青年基金(81900622);国家自然基金面上项目(81370586)。

摘　　要：我国结直肠癌发生率和致死率呈逐年上升趋势。转化生长因子-β(transforming growth factor-β,TGF-β)通过Smad、血管内皮生长因子、磷脂酰肌醇3-激酶等信号通路调节肿瘤的发生、侵袭及免疫逃逸。目前以TGF-β为靶点的治疗结直肠癌的药物研究包括受体激酶抑制剂、单克隆抗体、反义寡核苷酸等。本文就TGF-β信号通路与结直肠癌关系的研究进展作一综述。The prevalence and mortality of colorectal cancer are in an increasing tendency in recent years in China.Transforming growth factor-β(TGF-β)regulates the occurrence,invasion and immune escape through Smad,vascular endothelial growth factor and phosphatidylinositol 3-kinase signaling pathways.Nowadays,the drug for colorectal cancer targeting at TGF-βincludes receptor kinase inhibitors,monoclonal antibody and antisense oligonucleotides.This paper reviews the research progress of the correlation of TGF-βwith colorectal cancers.

关 键 词：结直肠癌 转化生长因子-Β 治疗 

分 类 号：R735.34[医药卫生—肿瘤]