瑞舒伐他汀钙片治疗老年血管性痴呆患者的疗效及对认知功能与事件相关电位的影响  

Effect of rosuvastatin calcium tablets on elderly patients with VD and its influence on cognitive function and event-related potential

作　　者：张珺[1] 李晓静 王华[2] ZHANG Jun;LI Xiaojing;WANG Hua(The First People's Hospital of Pingdingshan,Pingdingshan 467000,China;The First Affiliated Hospital of Henan University,Kaifeng 475000,China)

机构地区：[1]平顶山市第一人民医院,河南平顶山467000 [2]河南大学第一附属医院,河南开封475000

出　　处：《中国实用神经疾病杂志》2020年第21期1885-1890,共6页Chinese Journal of Practical Nervous Diseases

基　　金：河南省高等学校重点科研项目计划(编号:15A320005)。

摘　　要：目的探讨瑞舒伐他汀钙片治疗老年血管性痴呆(VD)患者的效果及对认知功能、事件相关电位的影响。方法选取平顶山市第一人民医院收治120例老年VD患者,采用随机数字表分为联合组和对照组各60例;2组均给予基础治疗措施+盐酸多奈哌齐治疗,联合组患者同时给予瑞舒伐他汀钙治疗;对比治疗前后2组患者的血脂指标、认知功能相关评分、事件相关电位(ERP)指标、临床疗效。结果治疗前,2组血清TG、TC、HDL-C、LDL-C测定值差异无统计学意义(P>0.05);治疗后,联合组的血清TG、TC、LDL-C测定值均低于对照组(P<0.05),联合组的HDL-C高于对照组(P<0.05);治疗前,2组MMSE评分、MoCA评分差异无统计学意义(P>0.05);治疗后,联合组的MMSE评分、MoCA评分均高于对照组(P<0.05);治疗前,2组的N1、N2、P2、P3潜伏期及P3波幅测定值差异无统计学意义(P>0.05);治疗后,联合组的N2、P2潜伏期测定值低于对照组(P<0.05),联合组的P3波幅测定值高于对照组(P<0.05);治疗后联合组的显效率53.33%、有效率41.67%优于对照组显效率33.33%、有效率56.67%、(P<0.05)。结论盐酸多奈哌齐联合瑞舒伐他汀钙可进一步调节老年VD患者的血脂及促进ERP参数恢复,从而改善其认知功能水平。Objective To explore the effect of rosuvastatin calcium tablets in the treatment of elderly patients with vascular dementia(VD),the impact on patients'cognitive function and event-related potentials.Methods 120 elderly VD patients in our hospital were selected and divided into a combined group and a control group of 60 patients using a random number table;both groups were given basic treatment measures+donepezil hydrochloride,and patients in the combined group were treated with rosuvastatin at the same time;comparative the blood lipid index,cognitive function related score,event-related potential(ERP)index and clinical efficacy of the patients in the two groups before and after treatment.Results Before treatment,there was no significant difference in serum TG,TC,HDL-C,and LDL-C between the two groups(P>0.05);after treatment,the serum TG,TC,and LDL-C values of the combined group were all lower than in the control group(P<0.05),the HDL-C of the combination group was higher than that of the control group(P<0.05);before treatment,there was no significant difference in MMSE score and MoCA score between the two groups(P>0.05);after treatment,the MMSE score and MoCA score of the combination group were higher than those of the control group(P<0.05);before treatment,there was no significant difference in the measured values of N1,N2,P2,P3 latency and P3 amplitude between the two groups(P>0.05);after treatment,the measured values of N2 and P2 latency of the combination group were lower than those of the control group(P<0.05),and the measured value of the P3 amplitude of the combination group was higher than that of the control group(P<0.05);after treatment,the effective rate of the combination group was 53.33%and the effective rate was 41.67%.It was superior to the control group with a significant rate of 33.33%and an effective rate of 56.67%(P<0.05).Conclusion Donepezil hydrochloride combined with rosuvastatin calcium can further regulate the blood lipids of elderly patients with VD and promote the recovery of ERP paramet

关 键 词：瑞舒伐他汀钙 老年 血管性痴呆 认知功能 事件相关电位 

分 类 号：R743[医药卫生—神经病学与精神病学]