病毒灭活血浆在慢加急性肝衰竭患者血浆置换中的临床价值  

The clinical value of virus inactivated plasma on plasma exchange in patients with chronic-on-acute liver failure

作　　者：李秋霞 LI Qiu-xia(Xuchang Central Hospital Affiliated to Henan University of Science and Technology,461000 Xuchang,Henan,China)

机构地区：[1]河南科技大学附属许昌市中心医院,河南许昌461000

出　　处：《临床消化病杂志》2020年第5期316-318,共3页Chinese Journal of Clinical Gastroenterology

摘　　要：[目的]探讨慢加急性肝衰竭患者行血浆置换时应用病毒灭活血浆的临床价值。[方法]选取150例经血浆置换治疗的慢加急性肝衰竭患者,随机分为观察组(n=75,病毒灭活血浆)及对照组(n=75,普通冰冻血浆);比较2组患者治疗效果及不良反应。[结果]观察组与对照组治疗后肝功能各指标、纤维蛋白原、国际标准化比值及临床治疗总有效率比较均差异无统计学意义(P>0.05);观察组治疗后C反应蛋白低于对照组[(16.24±3.19)mg/L vs(19.78±3.21)mg/L],治疗后凝血酶原时间活动度水平低于对照组[(48.95±12.4)%vs(53.36±12.5)%],不良反应发生率低于对照组(2.67%vs 13.33%),差异均有统计学意义(P<0.05)。[结论]血浆置换治疗慢加急性肝衰竭患者时,采用病毒灭活血浆具有较高的安全性,值得进一步探讨。[Objective]To evaluate the clinical value of virus inactivated plasma in patients with chronic-on-acute liver failure.[Methods]One hundred and fifty cases with chronic plus acute liver failure treated with plasma exchange were selected and randomly divided into control group and observation group.The therapeutic effect and adverse reactions between the two groups were compared.[Results]There was no difference in liver function index FIB,PTA,INR and total effective rate of clinical treatment between the two groups.CRP in the observation group was lower than that in the control group,PTA level was lower than that in the control group,and the incidence of adverse reactions was lower than that in the control group,the difference was statistically significant.[Conclusion]In the treatment of patients with chronic plus acute liver failure,the use of viral inactivation of plasma has a higher safety,which is worthy of further discussion.

关 键 词：慢加急性肝衰竭 血浆置换 普通冰冻血浆 病毒灭活血浆 

分 类 号：R575.3[医药卫生—消化系统]