疏肝解郁胶囊与舍曲林治疗老年轻中度抑郁症对照研究  

Comparative study of Shugan Jieyu Capsules and Sertraline in treatment of mild and moderate depression in the elderly

作　　者：张霞[1] 李云霞 张艳[1] 张媛媛 孙中华[1] ZHANG Xia;LI Yunxia;ZHANG Yan;ZHANG Yuanyuan;SUN Zhonghua(Department of Hongshankou Outpatient,Jingbei Medical District,Chinese PLA General Hospital,Beijing 100091,China;Department of Rehabilitation Medicine,People’s Liberation Army Hospital,984th,Beijing 100094,China)

机构地区：[1]解放军总医院京北医疗区红山口门诊部,北京100091 [2]解放军第984医院康复医学科,北京100094

出　　处：《中国医药导报》2020年第32期116-119,共4页China Medical Herald

摘　　要：目的观察中成药舒肝解郁胶囊与舍曲林治疗老年轻、中度抑郁症的临床效果、不良反应与安全性。方法选择于2016年4月—2019年10月在解放军第984医院康复医学科及解放军总医院京北医疗区红山口门诊部就诊的,符合中国精神障碍分类与诊断标准,年龄≥60岁,首次发病的老年轻、中度抑郁症患者75例,根据随机数字表法将其分为治疗组(舒肝解郁胶囊)38例和对照组(舍曲林)37例,共治疗观察8周,于治疗前、治疗第2、4、8周末分别采用汉密尔顿抑郁量表17项版(HAMD-17)、减分率、治疗伴发症状量表(TESS)评定治疗效果和不良反应。结果两组时间点及交互作用比较,差异均有高度统计学意义(均P<0.01),组间比较,差异无统计学意义(P>0.05)。组内比较:与治疗前比较,两组治疗2、4、8周HAMD-17评分均下降,差异均有统计学意义(P<0.05或P<0.01);组间比较:两组同期比较,差异均无统计学意义(均P>0.05)。两组总有效率比较,差异无统计学意义(P>0.05);治疗组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论舒肝解郁胶囊治疗老年轻、中度抑郁症与舍曲林治疗效果相当,不良反应明显少于舍曲林,是老年轻、中度抑郁症药物治疗的理想选择。Objective To observe the clinical efficacy,adverse reactions and safety of Shugan Jieyu Capsules and Sertraline in the treatment of mild and moderate depression in the elderly.Methods Seventy-five cases of mild and moderate depression patients from April 2016 to October 2019 in the Department of Rehabilitation Medicine of the People’s Liberation Army Hospital,984th and the Department of Hongshankou Outpatient of Jingbei Medical District of Chinese PLA General Hospital were selected,all patients in line with the Chinese classification and diagnostic criteria for mental disorders,aged≥60 years,first onset cases.According to the random number table method,they were divided into the treatment group(Shugan Jieyu Capsules)with 38 cases and the control group(Sertraline)with 37 cases,a total of eight weeks of treatment and observation.The Hamilton Depression Scale 17(HAMD-17),reduction rate,and treatment emergent symptom scale(TESS)were used to evaluate the efficacy and adverse reactions before treatment and at the end of the second,fourth and eighth week of treatment.Results The differences of time points and interaction between the two groups were highly statistically significant(all P<0.01),while the difference between the two groups was not statistically significant(P>0.05).Intra-group comparison:compared with before treatment,HAMD-17 scores in both groups decreased at two,four,and eight weeks after treatment,and the differences were statistically significant(P<0.05 or P<0.01).Comparison between groups:there was no statistically significant difference between the two groups in the same period(all P>0.05).There was no significant difference in total effective rate between the two groups(P>0.05).The incidence of adverse reactions in the treatment group was lower than that in the control group,with statistically significant difference(P<0.05).Conclusion Shugan Jieyu Capsules has the same efficacy as Sertraline in the treatment of mild and moderate depression in the elderly,and the adverse reactions are significantly

关 键 词：老年人 舒肝解郁胶囊 舍曲林 抑郁症 

分 类 号：R749.99[医药卫生—神经病学与精神病学]