外泌体在肝癌中的研究进展  

Research progress of exosomes in liver cancer

作　　者：郭新宇 李林强[1] 刘连新[1] Guo Xinyu;Li Linqiang;Liu Lianxin(Department of Liver Surgery,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院肝脏外科,150001

出　　处：《中华实验外科杂志》2020年第10期1968-1971,共4页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金面上项目(81772588、81773194)。

摘　　要：外泌体是由细胞分泌的纳米级囊泡,携带核酸、蛋白质等多种生物活性物质,密切参与细胞与细胞、微环境之间的信息交流和物质交换,在肝癌的诸多恶性生物学行为中发挥重要作用。笔者以外泌体在肝癌发生发展、侵袭转移、血管生成、耐药等方面的作用为切入点,就外泌体作为肝癌诊断、预后生物标志物的研究进展及其在肝癌治疗中的应用展开综述,为今后肝癌的诊疗提供新的思路。Exosomes are nanoscale vesicles secreted by cells,which carry a variety of bioactive substances such as nucleic acids and proteins,and closely participate in the exchange of information and substances between cells and microenvironment,and play an important role in many malignant biological behaviors of hepatocellular carcinoma(HCC).The author takes the role of Exosomes in the occurrence and development,invasion and metastasis,angiogenesis,and drug resistance of HCC as an entry point,and makes a review about the research progress of Exosomes as a biomarker for diagnosis and prognosis of HCC and the application of Exosomes in the treatment of HCC,so as to provide new ideas for the diagnosis and treatment of HCC in the future.

关 键 词：外泌体 肝癌 生物标志物 治疗 

分 类 号：R735.7[医药卫生—肿瘤]