急性区域性隐匿性外层视网膜病变全视野视网膜电图特征观察  

Manifestations of acute regional occult outer retinopathy in full-field electroretinogram

作　　者：包力[1] 杨涛[1] 王晓悦[1] Bao Li;Yang Tao;Wang Xiaoyue(Department of Ophthalmology,West China Hospital of Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院眼科,成都610041

出　　处：《中华眼底病杂志》2020年第11期833-837,共5页Chinese Journal of Ocular Fundus Diseases

摘　　要：目的观察急性区域性隐匿性外层视网膜病变(AZOOR)患者的全视野ERG(ff-ERG)特征。方法回顾性临床观察性研究。2017年6月至2019年6月在四川大学华西医院眼科确诊为AZOOR的42例患者62只眼(AZOOR组)纳入研究。所有患者眼底均无明显局限病灶。62只眼中,BCVA<0.1者16只眼,0.1≤BCVA≤0.5者27只眼,BCVA>0.5者19只眼。选取2018年6月至2019年1月在四川大学华西医院门诊就诊并通过眼科详细检查排除包括屈光不正在内的所有眼部病变的正常志愿者40名80只眼作为正常对照组。所有受检眼均采用德国Roland视觉电生理检查系统行ff-ERG检测。分别记录暗适应0.01 ERG、暗适应3.0 ERG、暗适应3.0振荡电位、明适应3.0 ERG及明适应30 Hz闪烁ERG各反应诱发出的波形峰时及振幅。两组之间ff-ERG各反应峰时及振幅的比较采用独立样本t检验;AZOOR组组内不同BCVA患眼之间ff-ERG各反应峰时和振幅的比较采用方差检验。结果与正常对照组比较,AZOOR组暗适应0.01 ERG b波(t=3.601、-6.120)、暗适应3.0 ERG a波和b波(t=2.627、-4.263、3.719、-5.866)、暗适应3.0振荡电位P2波(t=-6.625)、明适应3.0 ERG a波和b波(t=3.762、-3.612、3.648、-3.739)及明适应30 Hz闪烁ERG P波(t=-3.832)峰时均明显延迟,振幅降低,差异有统计学意义(P<0.05)。AZOOR组组内不同BCVA患眼比较,其暗适应0.01 ERG b波振幅(F=3.950)、暗适应3.0 ERG a波峰时和b波振幅(F=4.408、4.876)、暗适应3.0振荡电位P2波振幅(F=4.295)、明适应3.0 ERG b波振幅(F=4.344)以及明适应30 Hz闪烁ERG P波振幅(F=4.483)之间的差异有统计学意义(P<0.05);其余各反应波形峰时、振幅之间的差异均无统计学意义(P>0.05)。两两比较结果显示,与0.1≤BCVA≤0.5及BCVA>0.5者比较,BCVA<0.1者暗适应0.01 ERG b波、暗适应3.0 ERG b波、暗适应3.0振荡电位P2波、明适应3.0 ERG b波和明适应30 Hz闪烁ERG P波振幅均明显降低,暗适应3.0 ERG a波峰时明显延迟,差异�Objective To observe the full-field ERG (ff-ERG) characteristics of patients with acute regional occult outer retinopathy (AZOOR).Methods A retrospective observational study. From June 2017 to June 2019, 62 eyes of 42 patients (AZOOR group) who were diagnosed with AZOOR in the Department of Ophthalmology of West China Hospital of Sichuan University were included in the study. All patients had no obvious localized disease on the fundus. Among 62 eyes, BCVA of 16 eyes were <0.1, BCVA of 27 eyes were ≤0.5, and BCVA of 19 eyes were> 0.5. From June 2018 to January 2019, 40 normal volunteers (80 eyes) who attended the outpatient clinic of West China Hospital of Sichuan University and passed detailed ophthalmological examination to exclude all eye diseases including refractive errors were selected as the normal control group. All the examined eyes were tested with ff-ERG using the German Roland visual electrophysiological inspection system. The peak times and amplitudes of the waveforms induced by each response of dark adaptation 0.01 ERG, dark adaptation 3.0 ERG, dark adaptation 3.0 ERG, light adaptation 3.0 ERG, and light adaptation 30 Hz flicker ERG were recorded, respectively. The peak time and amplitude of each ff-ERG response between the two groups were compared by independent sample t test. The peak time and amplitude of each ff-ERG response between different BCVA eyes in the AZOOR group were compared by variance test.Results Compared with the normal control group, 0.01 ERG b wave of the dark adaptation of AZOOR group (t=3.601, -6.120), 3.0 ERG a wave and b wave of dark adaptation (t=2.627, -4.263, 3.719,-5.866), 3.0 Oscillation potential P2 wave of dark adaptation (t=-6.625), 3.0 ERG a wave and b wave of bright adaptation (t=3.762, -3.612, 3.648, -3.739) and 30 Hz flicker ERG P wave of bright adaptation (t=-3.832), all peak time of those were significantly delayed, the amplitude decreased, and the difference was statistically significant (P<0.05). Comparison of different BCVA eyes in the AZOOR group showed tha

关 键 词：视网膜疾病 视野测试 视网膜电描记术 

分 类 号：R774.1[医药卫生—眼科]