微气泡耦合生物反应器的研究进展  

Research progress of microbubble coupled bioreactor

作　　者：李辉 李干禄 何峰 许旭 田威龙 许晟 陈可泉 欧阳平凯 LI Hui;LI Ganlu;HE Feng;XU Xu;TIAN Weilong;XU Sheng;CHEN Kequan;OUYANG Pingkai(College of Biotechnology and Pharmaceutical Engineering,State Key Laboratory of Materials-Oriented Chemical Engineering,Nanjing Tech University,Nanjing 211816,Jiangsu,China;Jiangsu Jicui Industrial Biotechnology Research Institute Co.,Ltd.,Nanjing 21000,Jiangsu,China)

机构地区：[1]南京工业大学生物与制药工程学院,材料化学工程国家重点实验室,江苏南京211816 [2]江苏集萃工业生物技术研究所有限公司,江苏南京210000

出　　处：《化工进展》2020年第12期4758-4765,共8页Chemical Industry and Engineering Progress

基　　金：江苏省重点研发计划(社会发展)-面上项目(BE2018730);江苏省先进生物制造中心专项项目。

摘　　要：微气泡具有气液接触面积大、气体溶解速率快、上升速度慢和水中停留时间长等理化特征,非常适合于高气液传质效率需求的生物发酵过程。本文介绍了能够耦合生物反应器的几种微气泡发生装置,分别为微气泡分散器、微孔膜、流体振荡器耦合微孔膜和微气泡曝气搅拌桨;并简述了微气泡发生装置耦合搅拌式生物反应器、气升式生物反应器和生物膜反应器在生物反应过程的应用进展;最后回顾了二氧化碳微气泡在生物反应器的应用研究进展。指出微气泡耦合生物反应器的研究仍处于起步阶段,在放大规律和能耗方面仍处于研究空白。微气泡耦合生物反应器的发展对工业生物技术、石油化工、污水处理和资源再利用等的发展具有重要的意义。Microbubbles have several physical characteristics,such as large gas-liquid contact area,fast gas dissolution rate,slow rise speed,and long residence time in the water,etc.,which are suitable for the biological fermentation process with high gas-liquid mass transfer efficiency.In this study,several kinds of microbubble generators,like microbubble diffuser,microporous membrane,fluid oscillator coupled microporous membrane,and microbubble aeration agitator were introduced.The application of microbubble generator coupled stirred bioreactor,airlift bioreactor or biofilm reactor in biological process was described.The research progress of carbon dioxide microbubble bioreactor was summarized.This study reveals that the research of microbubble coupling bioreactor is in the early stage,and the study on the scaling up and energy consumption is limited.The continuous progress of microbubble coupled bioreactor is vital to the development of industrial biotechnology,petrochemical industry,sewage treatment,and resource reuse.

关 键 词：传质 生物反应器 气液两相流 曝气搅拌桨 微气泡 微孔膜 

分 类 号：TQ920.5[轻工技术与工程—发酵工程] Q815[生物学—生物工程]