miRNA液体活检与口腔鳞癌的研究进展  

Progressof miRNA in oral squamous cell carcinoma liquid biopsy

作　　者：樊斐 夏宇[1] 丁杰[1] FAN Fei;XIA Yu;DING Jie(Guizhou Provincial People′s Hospital;Guizhou Medical University,Guiyang,550000,China;不详)

机构地区：[1]贵州省人民医院,贵阳550000 [2]贵州医科大学,贵阳550000

出　　处：《实用医学杂志》2020年第21期3009-3012,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:81360366,81302169);贵州省社会发展攻关项目(编号:黔科合LH字[2014]7012号);贵州省高层次创新型人才培养对象(编号:GZSYQCC[2014]001);贵州省优秀青年科技人才培养对象(编号:黔科合平台人才(2017)5602);贵州省高层次留学人才创新创业项目(编号:留学人才择优资助合同(2018)04号);贵州省科技计划项目(编号:黔科合基础[2019]1198号,黔科合基础[2020]1Z064)。

摘　　要：口腔鳞状细胞癌是最常见的口腔肿瘤,全球每年有超过300000例新发病例被诊断,其中大多数患者就诊时已处于中晚期,整体预后较差。迄今为止,活组织检查依然是口腔癌诊断的金标准,但因其有创性及手术并发症导致其临床应用存在诸多限制。近年来,液体活检以其独特的简便性、无创性及可重复性在临床上得到了广泛的关注,展现了广阔的应用前景。本文就miRNA液体活检在口腔鳞癌的最新研究进展做一综述。Oral squamous cell carcinoma(OSCC)is the most common oral cancer.More than 300,000 new cases are diagnosed every year in the world,most patients are in middle or advanced stage and have a fairly poor prognosis.So far,biopsy are still the gold standard for diagnosis of oral cancer,butthere are still many limitations in its clinical application for its invasiveness and surgical complications.In recent years,liquid biopsy has attracted extensive attention in clinical practice due to its unique simplicity,non-invasiveness and repeatability,showing a broad application prospect.In this review,we summarize the new research findings among miRNA in oral squamous cell carcinoma liquid biopsy.

关 键 词：口腔鳞癌 MIRNA 液体活检 

分 类 号：R739.8[医药卫生—肿瘤]