喷雾干燥可控制备生物玻璃微球及其体外生物活性研究  

Controllable Preparation and In Vitro Bioactivity of Bioglass Microspheres via Spray Drying Method

作　　者：胡亚萍 田正芳 朱敏[1] 朱钰方[1,2] HU Yaping;TIAN Zhengfang;ZHU Min;ZHU Yufang(School of Materials Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;Hubei Key Laboratory of Processing and Application of Catalytic Materials,College of Chemical Engineering,Huanggang Normal University,Huanggang 438000,China)

机构地区：[1]上海理工大学材料科学与工程学院,上海200093 [2]黄冈师范学院化学化工学院,催化材料制备及应用湖北省重点实验室,湖北438000

出　　处：《无机材料学报》2020年第11期1268-1276,共9页Journal of Inorganic Materials

基　　金：上海市科委地方院校能力建设专项计划(17060502400)。

摘　　要：CaO-SiO2-P2O5体系生物玻璃(Bioglass,BG)微球具有良好的生物活性和骨传导性,在骨组织修复领域得到广泛研究与应用。传统熔融法制备BG粉体的能耗大、粉体形貌不可控、生物活性相对较低;溶胶–凝胶法制备BG粉体则需大量溶剂、制备周期长、不易量产。为快速、规模化制备形貌、粒径、化学组成可控的BG微球,本研究以水溶液为溶剂,以正硅酸四乙酯、磷酸三乙酯、四水硝酸钙为原料,采用喷雾干燥前驱体溶液方法制备BG微球,探讨喷雾干燥过程中进气风量、前驱体溶液浓度和进料速率等工艺参数对BG微球粒径的影响;前驱体溶液化学组成对BG微球的体外诱导磷灰石沉积能力的影响。结果表明,BG微球的粒径范围在40μm以下可控,且粒径随前驱体溶液浓度增大而增大,随进气风量增大而减小,进料速率则对微球粒径影响较小。不同化学组成的BG微球都具有良好的体外诱导磷灰石沉积能力,而且随CaO含量的增加而提高。The CaO-SiO2-P2O5 bioglass(BG)microspheres with good bioactivity and osteoconductivity have been extensively studied for bone tissue engineering.Traditional melting method for preparing BG powders is high energy consumption,and difficult to control the morphology of BG.While Sol-Gel technique for BG preparation requires a large amount of organic solvent,long preparation period and low mass production.For the rapid and scalable preparation of BG microspheres with controllable morphology,particle size and chemical composition,an efficient strategy of spray drying of precursor solution was proposed in this study,and the effects of process parameters including inlet air volume,precursor solution concentration and feed rate on the particle size of BG microspheres,and the effect of chemical composition on the apatite formation ability of BG microspheres in vitro were investigated.The results showed that the particle sizes of BG microspheres via spray drying could be controlled below 40μm,and the particle sizes of BG microspheres increased with the concentration of precursor solution,and decreased with the increase of inlet air volume,but the feed rate has a slight effect on the particle size of the microspheres.On the other hand,BG microspheres with different chemical compositions had good ability to induce apatite formation in vitro,and it increased with the increase of CaO content.Therefore,spray drying method would be promising for rapid and scalable preparation of BG microspheres.

关 键 词：喷雾干燥 生物玻璃 微球 磷灰石 

分 类 号：TQ174[化学工程—陶瓷工业]