Rhodium^Ⅲ/Silver^ⅠRelay Catalyzed C-H Aminomethylation with Imine Equivalents and Lewis Acid Catalyzed[4+2]Cycloaddition of Indoles with Triarylhexahydrotriazine  

作　　者：Ruixing Liu Yin Wei Min Shi 

机构地区：[1]State Key Laboratory of Organometallic Chemistry,Center for Excellence in Molecular Synthesis,University of Chinese Academy of Science,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,345 Lingling Road,Shanghai 200032,China

出　　处：《Chinese Journal of Chemistry》2020年第9期947-951,共5页中国化学（英文版）

基　　金：We are grateful for the financial support from the National Basic Research Program of China(No.(973J-2015CB856603);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB20000000);sioczz201808,the National Natural Science Foundation of China(Nos.21421091,21372250,21121062,21302203,20732008,21772037,21772226,21861132014,and 91956115).

摘　　要：Summary of main observation and conclusion A Rh^Ⅲ/Ag^Ⅰrelay-catalyzed C(sp^2)—H coupling of indoles with triarylhexahydrotriazine(THT)is reported in this context.Upon merging Rh^Ⅲ-catalyzed C(sp^2)—H bond activation and silver promoted THT dissociation,an efficient indole's C3 aminomethylation protocol is uncovered,providing C3 aminomethyl indoles in good yields and exhibiting potential applications for the synthesis of complicated bioactive compounds.We revealed the C3-selectivity of this reaction through a detailed mechanistic investigation.Meanwhile,during the examination of the reaction conditions,we discovered another[4+2]cycloaddition pathway to afford tetrahydro-indolo[3,2-c]quinoline scaffold products via silver or Lewis acid catalysis.

关 键 词：SILVER CATALYZED conclusion 

分 类 号：O62[理学—有机化学]