血清GROβ、TK1水平变化与结直肠癌发生发展的关系  

Relationship between Serum GROβand TK1 Levels and Tumor TNM Stage,Lymph Node Metastasis,Differentiation Degree and Depth of Invasion in Patients with Colorectal Cancer

作　　者：李琴 彭翠兰[2] 汪红英 LI Qin;PENG Cuilan;WANG Hongying(Panzhihua Third People's Hospital,Panzhihua,617061)

机构地区：[1]四川省攀枝花市第三人民医院,617061 [2]四川省攀枝花市中心医院,617067 [3]攀钢集团总医院,617023

出　　处：《实用癌症杂志》2020年第11期1774-1776,共3页The Practical Journal of Cancer

摘　　要：目的探讨结直肠癌患者血清胸苷激酶1(TK1)、生长相关癌基因产物β(GROβ)水平变化与肿瘤发生发展的关系。方法选取90例结直肠癌患者作为肿瘤组、90例结直肠镜检正常的志愿者作为对照组。采用ELISA法检测2组的血清TK1、GROβ水平;分析不同TNM分期、淋巴结转移情况、组织学分化程度、浸润深度的结直肠癌患者血清TK1、GROβ水平差异。结果肿瘤组患者的血清TK1、GROβ水平均高于对照组,差异具有统计学意义(P<0.05)。不同TNM分期、不同浸润深度的结直肠癌患者血清GROβ水平比较,差异具有统计学意义(P<0.05);不同淋巴结转移情况、不同组织学分化程度的结直肠癌患者血清GROβ水平组间比较,差异不具有统计学意义(P>0.05);不同TNM分期、不同组织学分化程度、是否发生淋巴结转移的结直肠癌患者血清TK1水平比较,差异具有统计学意义(P<0.05);不同浸润深度的结直肠癌患者血清TK1水平组间比较,差异不具有统计学意义(P>0.05)。结论结直肠癌患者血清GROβ、TK1水平升高,与肿瘤的发生及发展具有密切关系。Objective To investigate the relationship between serum thymidine kinase 1(TK1),growth-related oncogene productβ(GROβ)levels and tumorigenesis in patients with colorectal cancer.Methods 90 patients with colorectal cancer diagnosed by pathology(tumor group)and 90 volunteers with normal colorectal examination were selected as the control group.Serum TK1 was detected by immunoblotting enhanced chemiluminescence and ELISA.,GROβlevel;analysis of different TNM stage,lymph node metastasis,histological differentiation,depth of invasion of colorectal cancer patients with serum TK1,GROβlevels.Results The serum levels of TK1 and GROβin the tumor group were significantly higher than those in the control group(P<0.05).The serum GROβlevels in patients with colorectal cancer with different TNM stages and different infiltration depths were statistically significant(P<0.05).<0.05);There was no significant difference in serum GROβlevels between different lymph node metastasis and different histological differentiation of colorectal cancer patients(P>0.05);different TNM staging,different histological differentiation,whether or not occurred The serum TK1 levels in patients with colorectal cancer with lymph node metastasis were statistically significant(P<0.05).There was no significant difference in serum TK1 levels between colorectal cancer patients with different infiltration depth(P>0.05).Conclusion The levels of serum GROβand TK1 in patients with colorectal cancer are closely related to the occurrence and development of tumors.

关 键 词：结直肠癌 胸苷激酶1 生长相关癌基因产物β 发生发展 

分 类 号：R735.35[医药卫生—肿瘤] R735.37[医药卫生—临床医学]