宫颈癌组织中miRNA-21表达与其发展及预后的关系  

Relationship between miRNA-21 Expression and Tumor Development and Prognosis in Cervical Cancer

作　　者：张小燕 黄娟[1] 李晓丽[1] ZHANG Xiaoyan;HUANG Juan;LI Xiaoli(The First People's Hospital of Pingdingshan,Pingdingshan,467000)

机构地区：[1]河南省平顶山市第一人民医院,467000

出　　处：《实用癌症杂志》2020年第11期1790-1792,1796,共4页The Practical Journal of Cancer

摘　　要：目的探讨宫颈癌组织中的微小RNA-21(miRNA-21)表达与其发展及预后的关系。方法收集87例经病理学检查确诊的宫颈癌组织标本(宫颈癌组)、同期行宫颈检查确诊为宫颈炎的组织标本90例(对照组);采用实时荧光定量PCR技术检测2组标本中的miRNA-21表达情况,分析miRNA-21表达与宫颈癌FIGO分期、分化程度、病灶大小、淋巴结转移、肌层浸润情况的关系,探讨miRNA-21对患者预后的影响。结果宫颈癌组织中miRNA-21相对表达量显著高于对照组,差异具有统计学意义(P<0.05)。不同FIGO分期、是否发生淋巴结转移及3年不同随访结局的宫颈癌患者宫颈癌组织中miRNA-21相对表达量组间比较,差异具有统计学意义(P<0.05);不同病灶大小、不同肌层浸润深度的宫颈癌患者miRNA-21相对表达量组间比较差异不具有统计学意义(P>0.05)。采用Logistic回归分析,结果提示FIGO分期增高、发生淋巴结转移、miRNA-21相对表达量升高是宫颈癌患者不良预后的独立危险因素(P<0.05)。结论宫颈癌组织中miRNA-21相对表达量升高可能与肿瘤发展及患者不良预后有关。Objective To investigate the relationship between microRNA-21(miRNA-21)expression in cervical cancer tissues and tumor development and prognosis.Methods 87 specimens of cervical cancer tissue(cervical cancer group)diagnosed by pathology were collected,and 90 specimens of cervical cervicitis were diagnosed in the same hospital in the same period(control group).Two real-time quantitative PCR techniques were used to detect the two specimens.The expression of miRNA-21 in the specimens was analyzed.The relationship between miRNA-21 expression and FIGO stage,degree of differentiation,lesion size,lymph node metastasis and myometrial invasion was analyzed.The effect of miRNA-21 on the prognosis of patients was explored.Results The relative expression of miRNA-21 in cervical cancer tissues was significantly higher than that of the control group(P<0.05).There were different FIGO stages,lymph node metastasis and cervical cancer in 3 years of different follow-up outcomes.The relative expression of miRNA-21 was statistically significant(P<0.05).There was no significant difference in the relative expression of miRNA-21 between cervical cancer patients with different lesion size and different depth of infiltration.P>0.05);Logistic regression analysis showed that the increase of FIGO stage,lymph node metastasis and relative expression of miRNA-21 were independent risk factors for poor prognosis of cervical cancer patients(P<0.05).Conclusion Increased relative expression of miRNA-21 in cervical cancer tissue may be associated with promoting tumor development and increasing the risk of poor prognosis in patients.

关 键 词：宫颈癌 微小RNA-21 肿瘤发展 预后 

分 类 号：R737.33[医药卫生—肿瘤]