冷刀锥切术与宫颈环形电切术治疗宫颈鳞状上皮内瘤变的疗效比较  

Comparison on the Curative Effect of Cold Knife Coning and Loop ElectrosurgicalExcision Procedure on Cervical Intraepithelial Neoplasia

作　　者：黄伟娟[1] 高雁荣 郭舟群 HUANG Weijuan;GAO Yanrong;GUO Zhouqun(Anyang Tumor Hospital,Anyang,455000)

机构地区：[1]安阳市肿瘤医院,455000

出　　处：《实用癌症杂志》2020年第11期1853-1856,共4页The Practical Journal of Cancer

摘　　要：目的探讨冷刀锥切术(CKC)与宫颈环形电切术(LEEP)治疗宫颈鳞状上皮内瘤变的疗效。方法选取120例宫颈鳞状上皮内瘤变患者,随机数表法分为两组,对照组60例行CKC治疗,观察组60例行LEEP治疗,比较两组围手术期指标、锥切组织大小、术后并发症、治愈率和复发率。结果观察组患者的术中出血量、手术时间、术后住院时间、住院费用均少于对照组;观察组切除组织的锥高、锥切面积小于对照组,差异有统计学意义(P<0.05)。两组术后宫颈粘连、切口感染、术后出血发生率相比,差异无统计学意义(P>0.05)。术后随访1年,两组患者术后3、6个月的复发率比较无差异,观察组术后12个月复发率高于对照组,差异有统计学意义(P<0.05);观察组、对照组的治愈率分别为83.33%(50/60)、90.00%(54/60),差异无统计学意义(χ^2=1.154,P=0.283)。结论与CKC相比,LEEP手术时间短、术中出血量更低、锥切组织更小、住院天数和费用较少,但宫颈鳞状上皮内瘤变患者术后1年内复发率更高,临床可根据实际情况进行选择。Objective To explore the curative effect of cold knife coning(CKC)and loop electrosurgical excision procedure(LEEP)on cervical intraepithelial neoplasia(CIN).Methods A total of 120 CIN patients who were treated were divided into the control group(CKC)and the observation group(LEEP)by random number table method,60 cases in each group.The perioperative indexes,size of coning tissues,postoperative complications,cure rate and recurrence rate were compared between the 2 groups.Results The intraoperative blood loss,operation time,postoperative hospitalization time and hospitalization cost in the observation group were fewer than those of the control group,vertebral height and coning area of excised tissue were smaller than those of the control group(P<0.05).There was no significant difference in the incidence of postoperative cervical adhesion,incision infection and postoperative bleeding between the 2 groups(P>0.05).After 1 year of postoperative follow-up,there was no significant difference in the recurrence rate at 3 months and 6 months after surgery between the 2 groups.The recurrence rate at 12 months after surgery in the observation group was higher than that of the control group(P<0.05).There was no significant difference in cure rate between the observation group and the control group[83.33%(50/60)vs 90.00%(54/60)](χ^2=1.154,P=0.283).Conclusion Compared with CKC,operation time of LEEP is shorter,intraoperative blood loss is less,coning tissues are smaller,and hospitalization time and cost are fewer.However,recurrence rate within 1 year after surgery is higher in CIN patients.Clinically,the surgical methods can be chose according to the actual situations.

关 键 词：冷刀锥切术 宫颈鳞状上皮内瘤变 宫颈环形电切术 疗效 

分 类 号：R737.33[医药卫生—肿瘤]