氨磺必利对BZD药物依赖精神分裂症患者认知功能及SAS评分的影响  

Effect of amisulpride on cognitive function and SAS score in patients with BZD drug-dependent schizophrenia

作　　者：侯建春 程奥博 李小宁 陈莎莎 李鑫 陈薇 高海波 HOU Jianchun;CHENG Aobo;LI Xiaoning;CHEN Shasha;LI Xin;CHEN Wei;GAO Haibo(Kailuan Mental Health Center Affiliated to North China University of Technology,Tangshan,063001)

机构地区：[1]华北理工大学附属开滦精神卫生中心,唐山063001

出　　处：《中国药物依赖性杂志》2020年第5期345-349,共5页Chinese Journal of Drug Dependence

基　　金：河北省卫生厅科研课题项目(20171432)。

摘　　要：目的:探讨氨磺必利对苯二氮艹卓类(benzodiazepines,BZD)药物依赖精神分裂症患者认知功能及SAS评分的影响。方法:选择2018年2月-2019年5月收治的BZD成瘾的精神分裂症患者86例,每组43例,常规组采用奥氮平治疗,氨磺必利组采用奥氮平联合氨磺必利治疗,2个月后,观察两组患者治疗后的认知功能、SAS和SDS评分、SCoRS和PANSS评分及治疗期间发生的毒副作用。结果:氨磺必利组患者的非持续性错误、持续性错误、思维灵活性、连线A、B时间均少于常规组(P<0.05),其他项目差距较小(P>0.05)。氨磺必利组在颢叶认知功能及顶叶认知功能内功能均好于常规组(P<0.05);治疗前,各组在PANSS评分差距较小(P>0.05),治疗后,常规组与氨磺必利组患者与同组治疗前相比PANSS评分均降低(P<0.05),且氨磺必利组评分低于常规组(P<0.05);治疗前,各组在SCoRS评分差距较小(P>0.05),治疗后,常规组与氨磺必利组患者与同组治疗前相比SCoRS评分均降低(P<0.05),且氨磺必利组患者评分低于常规组(P<0.05),负性情绪指标治疗前两组患者差距较小(P>0.05),治疗后,常规组与氨磺必利组患者与同组治疗前相比负性情绪均下降(P<0.05),且氨磺必利组下降更为显著(P<0.05);常规组和氨磺必利组之间期间出现不良反应,主要表现在睡眠过多、心率加快、口渴及坐立不宁等,两组不良反应发生情况接近(P>0.05)。结论:BZD药物依赖精神分裂症患者采用氨磺必利治疗,有助于认知功能提高,负性情绪改善,且毒副作用少。Objective:To investigate the effect of amisulpride on cognitive function and SAS score in patients with BZD drug-dependent schizophrenia. Methods:Eighty-six cases of BZD addicted schizophrenia were selected from February 2018 to May 2019, 43 cases in each group. The conventional group was treated with olanzapine, and the sulfamethoxazole group was treated with olanzapine and sulfamethoxazole. Two months later, the cognitive function, SAS and SDS scores, schors and PANSS scores of the two groups and the side effects during the treatment were observed. Results:Patients in the amisulpride group had less nonpersistent errors, persistent errors, flexibility of thinking, time to connect A and B than those in the conventional group(P<0.05), and the gaps in other items were smaller(P>0.05). Cognitive function of Haoli lobe and parietal lobe of Biley group were better than those of conventional group(P<0.05). Before treatment, the PANSS score of each group had little change(P>0.05). After treatment, both groups were lower than those of the same group before treatment(P<0.05), and the scores of amisulpride group were lower than the conventional group(P<0.05);before treatment, the changes of SCoRS score of each group were small(P>0.05). After treatment, the SCoRS scores of patients in the conventional group and amisulpride group were lower than those in the same group before treatment(P<0.05), and the patients in the amisulpride group had lower scores than conventional Group(P<0.05), the difference between the two groups of patients of the negative emotion index before treatment was small(P>0.05). After treatment, the patients in the conventional group and the amisulpride group had decreased negative emotion compared to the same group before treatment(P<0.05), and the amisulpride group had a more significant decrease(P<0.05);adverse reactions occurred between the conventional group and amisulpride group, mainly excessive sleep, increased heart rate, thirst and restlessness, etc., the incidence of adverse reactions in the tw

关 键 词：精神分裂症 BZD药物依赖 氨磺必利 认知功能 SAS评分 

分 类 号：R749[医药卫生—神经病学与精神病学]