帕金森病患者合并抑郁的临床特点和相关危险因素及其对生活质量影响的分析  

Analysis of clinical characteristics and related risk factors of Parkinson′s disease patients complicated with depression and its influence on quality of life

作　　者：刘波[1] 莫颖敏[1] 韦春英[1] 陶然[1] 韩敏[1] LIU Bo;MO Ying-min;WEI Chun-ying(The Cadre Ward of the Department of Neurology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China)

机构地区：[1]广西壮族自治区人民医院神经内科干部病区,南宁530021

出　　处：《中国临床新医学》2020年第11期1152-1156,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的分析帕金森病患者合并抑郁的临床特点、相关危险因素及其对生活质量的影响。方法收集2017-10~2018-11广西壮族自治区人民医院门诊及病房诊治的帕金森病98例患者的临床资料,采用HAMD-17评分方法评估患者抑郁情况,以是否合并抑郁进行分组,并行组间分析;对帕金森病患者教育年限、病程、Hoehn-Yahr(H-Y)分级、正常生活能力评定(ADL)量表评分、统一帕金森病评定量表-Ⅲ(UPDRS-Ⅲ)评分、使用左旋多巴每日剂量、单胺氧化酶B(MAO-B)抑制剂的使用比例、异动症进行Logistic回归分析。结果98例帕金森病患者中41例合并抑郁,抑郁的发生率为41.84%。抑郁组的病程、H-Y分级、UPDRS-Ⅲ评分、使用左旋多巴每日剂量高于非抑郁组,异动症的发生率、MAO-B抑制剂使用比例高于非抑郁组,ADL评分、受教育年限低于非抑郁组,差异均有统计学意义(P<0.05)。两组患者的平均年龄、发病年龄、性别、简易智能(MMSE)量表评分、吸烟、饮酒、便秘、嗅觉减退的发生率等差异均无统计学意义(P>0.05)。Logistic回归分析结果显示H-Y分级(OR=7.959)、UPDRS-Ⅲ评分高(OR=1.480)及有异动症(OR=1.417)是帕金森病患者伴发抑郁的危险因素(P<0.05)。帕金森病并发抑郁组患者的生活质量较非抑郁组患者受影响严重(P<0.05)。结论抑郁在帕金森病患者中很常见,抑郁的发生很有可能与H-Y分级、UPDRS-Ⅲ评分高及异动症相关,其对帕金森患者的生活质量影响严重。Objective To analyze the clinical characteristics and related risk factors of Parkinson′s disease(PD)patients complicated with depression and its influence on quality of life.Methods From October 2017 to November 2018,the clinical data of 98 patients with PD diagnosed and treated in the Outpatient Department and Inpatient Ward of the People′s Hospital of Guangxi Zhuang Autonomous Region were collected.Hamilton Depression Rating Scale 17(HAMD-17)was employed to assess the depression of the patients.The patients were divided into groups according to whether they had depression or not and intergroup analysis was performed.Logistic regression analysis was carried out on the years of education,course of the disease,Hoehn-Yahr(H-Y)grade,Activities of Daily Living(ADL)Scale scores,Unified Parkinson′s Disease Rating Scale PartⅢ(UPDRS-Ⅲ)scores,daily dose of levodopa,the proportion of monoamine oxidase B(MAO-B)used and dyskinesia of the patients with PD.Results Of the 98 PD patients,41 cases had depression,and the incidence of depression was 41.84%.The depression group had significantly longer PD duration,higher H-Y grade and UPDRS-Ⅲscores,and higher daily dose of levodopa than the non-depression group(P<0.05).The incidence of dyskinesia,and the proportion of MAO-B used in the depression group were significantly higher than those in the non-depression group(P<0.05).The years of education and ADL scores in the depression group were significantly less than those in the non-depression group(P<0.05).There were no statistically significant differences between the two groups in average age,age of onset,gender,Mini-mental State Examination(MMSE)score,smoking,drinking,constipation and incidence of anosmia(P>0.05).The results of Logistic regression analysis showed that H-Y grade(OR=7.959),high UPDRS-Ⅲscore(OR=1.480)and having dyskinesia(OR=1.417)were the risk factors of PD patients complicated with depression(P<0.05).The quality of life of the patients with PD complicated with depression was significantly impaired com

关 键 词：帕金森病 抑郁 相关危险因素 生活质量 

分 类 号：R742.5[医药卫生—神经病学与精神病学]